PURPOSE A predictive method was proposed to predict solubility of drugs in water-ethanol mixtures at various temperatures based on the Jouyban-Acree model. The model requires the experimental solubility data of the drug in mono-solvent systems. METHODS The accuracy of the proposed prediction method was evaluated using collected experimental solubility data from the literature. The proposed me...

Strong foam can be generated in porous media containing oil, resulting in incremental oil recovery; however, oil recovery factor is restricted. A large fraction of oil recovered by foam flooding forms an oil-in-water emulsion, so that costly methods may need to be used to separate the oil. Moreover, strong foam could create a large pressure gradient, which may cause fractures in the reservoir. ...

PURPOSE To provide predictive cosolvency models, the Abraham solvation parameters of solutes and the solvent coefficients were combined with the Jouyban-Acree and the log-linear models. These models require two and one solubility data points to predict the solubility of drugs in water-cosolvent mixtures. Ab initio prediction methods also were employed and the results were discussed. METHOD Th...

Aim: 1) To increase water solubility of indomethacin drug using mixed solvency approach. 2) To employ use of non toxic solubilizers for increasing solubility of a poorly water soluble drug. Study Design: Trial and error based experimental study. Place and Duration of Study: School of Pharmacy, Devi Ahilya Vishwavidyalaya, UTD, Takshashila Campus, Indore, India and College of Pharmacy, IPS Acade...

Aqueous core/polymer shell microcapsules with mononuclear and polynuclear core morphologies have been formed by internal phase separation from water-in-oil emulsions. The water-in-oil emulsions were prepared with the shell polymer dissolved in the aqueous phase by adding a low boiling point cosolvent. Subsequent removal of this cosolvent (by evaporation) leads to phase separation of the polymer...

The bimolecular association rate constant (kon) and dissociation rate constant (koff) of the complex between fluorescein-labeled S-peptide analogues and folded S-protein are reported. This is the first kinetic study of a protein folding reaction in which most of the starting material is already folded and only a small part (one additional helix) becomes ordered; it provides a folding landscape ...

A new heterogeneous catalytic system, phase-boundary catalysis, for epoxidation of alkene with aqueous H2O2 is proposed. Amphiphilic titanium-loaded zeolite particles, a part of the external surface of which was covered with hydrophobic alkyl groups and the rest being left hydrophilic, were prepared by deposition of titanium species from titanium(IV) tetra-2-propoxide and attachment of octadecy...

Snakehead fish extract has been recognized for its potential in healing postoperative wounds and burns. The contains albumin, which aids tissue formation processes. To create a high-quality wound drug, the needs to be formulated into concentrated form combined with solvent that can effectively dissolve active substances. Understanding solubility profile of composition is crucial this purpose. T...