OBJECTIVES To compare the efficacy and safety of percutaneous coronary intervention using second-generation drug-eluting stents with those of coronary artery bypass grafting among patients with multivessel disease and/or unprotected left main coronary artery disease in terms of mortality, myocardial infarction, repeat revascularization, and angina. BACKGROUND Although coronary artery disease ...

non-insulin dependent diabetes mellitus (niddm) is a common disease entity in patients with coronary artery disease (cad). diabetic ketoacidosis (dka) is not only one of the major complications of diabetes mellitus but also a significant challenging clinical entity for the patients undergoing any elective or emergency surgery. coronary artery bypass grafting (cabg) being done in a patient with ...

although coronary artery disease (cad) is not common among individuals younger than 40-45 years of age, a small percentage of this age group needs to undergo surgical revascularization because of cad. why some people are at higher risk of developing premature cad is not clearly known. increased number of traditional risk factors or genetic predisposition may play significant roles in this regar...

We are pleased to announce to our readers the launch of a new section in Circulation. The purpose is to provide a perspective on contemporary clinical trials in cardiovascular medicine. These trials need not be published in Circulation but must fulfill a minimum set of criteria so as to allow a multidisciplinary discussion of the trial across at least three of the following domains: clinical pr...

Background: Inadequate depth of anesthesia leads to release of stress hormones. Electroencephalographic monitoring by bispectral index is a guide to asses the depth of anesthesia. The aim of the present study was to measure the serum cortisol levels as an index of stress response in patients who are candidates for coronary artery bypass graft surgery in two groups of patients. Methods: Seventy-...

Introduction: Although coronary endarterectomy is not an ideal procedure, it is the only available option for cardiac surgeons in some patients with diffuse coronary artery disease. Based on the majority of conducted studies, the results of coronary endarterectomy (including survival, graft patency, and recurrence of the symptoms of myocardial ischemia) are less prevalent than standard coronary...

Background—Clopidogrel inhibits intimal hyperplasia in animal studies and therefore may reduce saphenous vein graft (SVG) intimal hyperplasia after coronary artery bypass grafting. The Clopidogrel After Surgery for Coronary Artery DiseasE (CASCADE) study was undertaken to evaluate whether the addition of clopidogrel to aspirin inhibits SVG disease after coronary artery bypass grafting, as asses...