نتایج جستجو برای: core promoter

تعداد نتایج: 301283  

Journal: :Genome research 2014
Danny Zeevi Shai Lubliner Maya Lotan-Pompan Eran Hodis Rita Vesterman Adina Weinberger Eran Segal

Recent studies have shown a surprising phenomenon, whereby orthologous regulatory regions from different species drive similar expression levels despite being highly diverged in sequence. Here, we investigated this phenomenon by genomically integrating hundreds of ribosomal protein (RP) promoters from nine different yeast species into S. cerevisiae and accurately measuring their activity. We fo...

Journal: :Journal of bacteriology 1995
M Urh Y Flashner A Shafferman M Filutowicz

The R6K gamma origin core contains the P2 promoter, whose -10 and -35 hexamers overlap two of the seven binding sites for the R6K-encoded pi protein. Two mutations, P2-201 and P2-203, which lie within the -35 region of P2, are shown to confer a promoter-down phenotype. We demonstrate here that these mutations prevent replication of a gamma origin core plasmid. To determine whether or not the re...

Journal: :Current Biology 2002
Xiao-Yong Li Sukesh R Bhaumik Xiaocun Zhu Lei Li Wu-Cheng Shen Bharat L Dixit Michael R Green

The general transcription factor TFIID is composed of the TATA box binding protein (TBP) and multiple TBP-associated factors (TAFs). In yeast, promoters can be grouped into two classes based on the involvement of TAFs. TAF-dependent (TAF(dep)) promoters require TAFs for transcription, and TBP and TAFs are present at comparable levels on these promoters. TAF-independent (TAF(ind)) promoters do n...

2016
Yuan Li Masahiko Ito Suofeng Sun Takeshi Chida Kenji Nakashima Tetsuro Suzuki

The core promoter of hepatitis B virus (HBV) genome is a critical region for transcriptional initiation of 3.5 kb, pregenome and precore RNAs and for the viral replication. Although a number of host-cell factors that potentially regulate the viral promoter activities have been identified, the molecular mechanisms of the viral gene expression, in particular, regulatory mechanisms of the transcri...

Journal: :Acta biochimica Polonica 2008
Piotr Bonarek Sylwia Kedracka-Krok Barbara Kepys Zygmunt Wasylewski

The in vitro formation of transcription complexes with Escherichia coli RNA polymerase was monitored using fluorescence anisotropy measurements of labeled fragments of DNA. The multicomponent system consisted of holo or core RNA polymerase (RNAP) and lac or gal promoter fragments of DNA (in different configurations), in the presence or absence of CRP activator protein (wt or mutants) with its l...

2013
Marie Bobowski Audrey Vincent Agata Steenackers Florent Colomb Isabelle Van Seuningen Sylvain Julien Philippe Delannoy

Recent data have underlined a possible role of G(D3) synthase (GD3S) and complex gangliosides in Estrogen Receptor (ER) negative breast cancer progression. Here, we describe the main transcript of the GD3S coding gene ST8SIA1 expressed in breast tumors. We characterized the corresponding core promoter in Hs578T breast cancer cells and showed that estradiol decreases ST8SIA1 mRNA expression in E...

Journal: :Nucleic Acids Research 2005
Kobe Florquin Yvan Saeys Sven Degroeve Pierre Rouzé Yves Van de Peer

DNA encodes at least two independent levels of functional information. The first level is for encoding proteins and sequence targets for DNA-binding factors, while the second one is contained in the physical and structural properties of the DNA molecule itself. Although the physical and structural properties are ultimately determined by the nucleotide sequence itself, the cell exploits these pr...

ژورنال: Medical Laboratory Journal 2016
Javid , Naeme, Moradi , Abdolvahab, Salarneia , Farzane, Bazori , Masoud , Khodabakhshi , Behnaz , Tabarraei , Alijan , Vakili , Mohammad Ali , Zhand , Sare ,

Abstract       Background and objective: Hepatitis B virus (HBV) is a DNA virus with high tendency toward hepatic tissue. There are currently about 3 million HBV-infected people and 350 to 400 million chronic carriers of this virus in the world. X protein plays a role in the over-expression of oncogenes, carcinogenicity of liver cells and overlaps with the basal co...

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