Dermal drug delivery is highly preferred by patients due to its several advantages. Protein therapeutics have attracted huge attention recently. Since dermal delivery of proteins encounter problems, in this investigation, zinc oxide nanoparticles and calcium phosphate nanoparticles were compared as enhancers for dermal permeation of albumin. Albumin was applied simultaneously with zinc oxide na...

Acrylic bone cements have been used for about 40 years to fix artificial prosthesis to bone structure. The properties of the acrylic bone cement mostly depend on the characteristics of the beads, which are the main component of the solid part of the cement. In this work beads of poly(methyl methacrylate-co-styrene) were synthesized by suspension polymerization. The objective of this study was t...

Novel cationic pentablock copolymers based on poly(2-diethylaminoethylmethacrylate) (PDEAEM) and Pluronic F127 were evaluated as non-viral gene delivery vectors from a physiochemical point of view for stability and transfection efficiency in complete growth media. A novel strategy was introduced to sterically stabilize the polyplexes of such Pluronic-based cationic polymers against aggregation ...

in this research nickel zinc ferrite nanoparticles with composition of ni1-xznxfe2o4 (where x=0, 0.3, 0.7, 1) were synthesized by a sol-gel method at 600 °c for 5 hours. the structure of nanoparticles was studied using x-ray diffraction pattern. the lattice parameter of ferrite nanoparticles was calculated and indicates lattice constant of nanoparticles depend on zinc concentration. the crystal...

Magnetothermally responsive drug-loaded micelles were designed and prepared for cancer therapy. These specially designed micelles are composed of the thermo-responsive star-block copolymer poly(ε-caprolactone)-block-poly(2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol)methacrylate) and Mn, Zn doped ferrite magnetic nanoparticles (MZF-MNPs). The thermo-responses of 6sPCL-b-P(MEO2M...

This study developed novel triblock pH-responsive polymeric micelles (PMs) using cholic acid-polyethyleneimine-poly-L-arginine (CA-PEI-pArg) copolymers. PEI provided pH sensitivity, while the hydrophilic cell-penetrating pArg peptide promoted cellular PM internalization. The copolymers self-assembled into PMs in aqueous solution at above the critical micelle concentration (2.98 × 10-7 M) and en...

BACKGROUND Gold nanoparticles are useful tools for biological applications due to their attractive physical and chemical properties. Their applications can be further expanded when they are functionalized with biological molecules. The biological molecules not only provide the interfaces for interactions between nanoparticles and biological environment, but also contribute their biological func...

Stem cell therapy has emerged as the most vibrant area of research, due to capacity stem cells for self-renewal and differentiation into different types lines upon their culture. But lately, scientists become increasingly aware limitations conventional 2D culture media, several key drawbacks associated with this model, such immune response transplantation, animal pathogen contamination, complic...

Nobel metal nanoparticles have drawn significant attention for a wide range of new applications in various fields including biology and medicine. Research work during the last two decades have clearly demonstrated that the properties of nanoparticles, in particular silver nanoparticles are strongly influenced by shape, size and size distribution, which is dictated by the synthetic method adopte...