Background: Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer leading to cancer-related death in children. Most infants with ALL harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of the disease. Mixed-lineage leukemia-rearrangement (MLL-rearrange...

background: approximately 205 million pregnancies occur each year in the worldwide. on the other hand, spontaneous abortion has been reported in 15-20% of all diagnosed pregnancies. the most common cause of spontaneous abortion is chromosomal abnormalities of the embryo. robertsonian translocation carriers specially 21-14 are the most common balanced rearrangement among the carrier couples with...

During their common time in Austria (and Germany), Fritz Heider and Egon Brunswik knew each other quite well, meeting for professional interchange of their ideas and thoughts, which they mutually highly respected (compare the late autobiography by Heider, 1983). They both worked on problems of how the human being copes with his environment; later on (in the early 50s), they both were regarded a...

This paper presents a diagnostic technique that subsumes two complementary approaches to diagnosis of discrete-event systems (DESs), namely the diagnoser approach and the active system approach. The more significant shortcomings of such approaches are, on the one side, the need for the generation of the global system model and, on the other, the completion of the system observation before start...

It is well observed that individual behaviour can have an effect on the efficiency of queueing systems. The impact of this behaviour on the economic efficiency of public services is considered in this paper where we present results concerning the congestion related implications of decisions made by individuals when choosing between facilities. The work presented has important managerial implica...

BACKGROUND Interest in resilience has increased in recent years. The U.S. military focus is on personal health and adaptation following exposure to battle, while the civilian interest centers on adjustments subsequent to disastrous events. Coping skills are also relevant, yet the relationships between coping and resilience are unclear. OBJECTIVE This brief review examines personal resilience ...

This paper introduces a system that uses brainwaves, or EEG (electroencephalogram), information to compose and play music in real-time. The system composes music using generative grammars and transition rules controlled by means of information extracted from the EEG of the subject. The paper starts by noting the various attempts at the design of systems that make music from the EEG signals, fol...

We compare the strategy found by the optimal control theory in a complex molecular system according to the active subspace coupled to the field. The model is the isomerization during a Cope rearrangement of Thiele's ester that is the most stable dimer obtained by the dimerization of methyl-cyclopentadienenylcarboxylate. The crudest partitioning consists in retaining in the active space only the...

Calculations on the role of tunneling in the degenerate Cope rearrangements of semibullvalene (1) and barbaralane (3) predict that, at temperatures below 40 K, tunneling from the lowest vibrational level should make the temperature-independent rate constants k = 1.43 x 10(-3) s(-1) and k = 7.28 x 10(-9) s(-1), respectively. An experiment, using semibullvalene-2(4)-d(1), is proposed to test the ...