A key step in the substitution of a new organelle mutant throughout a population is the generation of germ-line cells homoplasmic for that mutant. Given that each cell typically contains multiple copies of organelles, each of which in turn contains multiple copies of the organelle genome, processes akin to drift and selection in a population are responsible for producing homoplasmic cells. This...

Growth, feed conversion ratio and fillet composition of rainbow trout (initial weight of 9.99±0.109)were investigated in a 6x2 factorial design experiment employing two levels of digestible energy (DE) (2900 and 3500kcal.kg-1) and six feeding rates (1.0%, 2.0%, 3.0%, 4.0%,5.0% of the body weight,(BW) day-1 and to satiation) for 60 days. Specific growth rate (SGR) was highest at 5.0% ration in b...

BACKGROUND Tuberculosis (TB) continues to be a major global health problem. While progress has been made to improve TB cure rates, South Africa's 76 % smear-positive pulmonary TB (PTB) case cure rate remains below the WHO target of 85 %. We report on the trends of TB smear non-conversion and their predictors at the end of an intensive phase of treatment, and how this impacted on treatment outco...

Very rapid rates of gene conversion were observed between duplicated alpha-amylase-coding sequences in Drosophila melanogaster. This gene conversion process was also seen in the related species Drosophila erecta. Specifically, there is virtual sequence identity between the coding regions of the two genes within each species, while the sequence divergence between species is close to that expecte...

Four-wave mixing (FWM) in semiconductor optical amplifiers is an attractive mechanism for wavelength conversion in wavelength-division multiplexed (WDM) systems since it provides modulation format and bit rate transparency over wide tuning ranges. A series of systems experiments evaluating several aspects of the performance of these devices at bit rates of 2.5 and 10 Gb/s are presented. Include...

PURPOSE To assess clinical factors, histopathologic diagnoses, operative time and differences in complication rates between women undergoing laparoscopy or laparotomy to diagnose and treat an adnexal mass and their association with laparoscopy failure. METHODS In this prospective study, 210 women were invited to participate and 133 of them were included. Eighty-eight women underwent laparotom...

Analgesia prescribing is fundamental to a patient's journey, affecting length of stay and patient experience. Laminated prompts are used throughout the NHS Foundation Trust to aid doctors prescribing. A baseline questionnaire was carried out to gather doctors' prescribing habits and current ability to convert opioids to their morphine equivalent. Ninety three percent of doctors said they were m...

BACKGROUND Organ availability is a consistently limiting factor in transplant surgery. A primary driver of this limitation is donor conversion rate, which is defined as the percentage of eligible donors for whom procurement is actually performed. An alternative way to increase organ availability is through improved utilization of organs from donors after cardiac death (DCD). Recently, a concert...

Background The crystallinity of cellulose is a principal factor limiting the efficient hydrolysis of biomass to fermentable sugars or direct catalytic conversion to biofuel components. We evaluated the impact of TFA-induced gelatinization of crystalline cellulose on enhancement of enzymatic digestion and catalytic conversion to biofuel substrates. Results Low-temperature swelling of cotton li...

The evolutionary importance of meiosis may not solely be associated with allelic shuffling caused by crossing-over but also have to do with its more immediate effects such as gene conversion. Although estimates of the crossing-over rate are often well resolved, the gene conversion rate is much less clear. In Arabidopsis, for example, next-generation sequencing approaches suggest that the two ra...