Over the past 30 years as the expense and complications involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems. Bilayer tablet is new era for the successful development of controlled release formulatio...

megaloporous controlled release tablets of diclofenac sodium (ds) were prepared with two kinds of granules. one of them is the restraining-phase matrix granule (rmg) and it controls the release rate of the drug. the other one is the soluble housing-phase matrix granule (hmg) and controls liquid penetration into the system. carnauba wax and eudragit l 100 polymers were used to constitute the res...

Microspheres formulated from poly (D,L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres ...

A new, novel promising technology for obtaining controlled release and enhancing the bioavailability is a combination of mucoadhesion principle and microencapsulation to result in mucoadhesive microcapsules. Mucoadhesive microcapsules consist of either entirely of a mucoadhesive polymer or having an outer coating enclosing the drug particles. They facilitate an intimate and prolonged contact wi...

        Controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (HPMC) as the matrix former. The effects of the viscosity grades of HPMC and HPMC/lactose ratio and ethylcellulose (EC)/sodium carboxymethylcellulose (NaCMC) and their concentrations on the release behavior of phenobarbital from HPMC matrices wer...

in this paper, carbon nanotubes (cnts) were added into chitosan (cs) hydrogels in the form of chitosan modified cnts (cs-cnts) composites to prepare carbon nanotubes hydrogels (cnts-gel). the products, named cs-mwcnts, were characterized by scanning electron microscope (sem) and fourier transform infrared (ftir) spectroscopy. swelling properties and effect of ph on controlled release performanc...

Novel drug delivery systems for controlled-release of opioid agonists as a long time painkillers or opioid antagonists for opium, heroin, and alcohol addiction are under development or in clinical use today. In this article, the field of “new drug delivery systems” is momentarily reviewed from the viewpoint of the marketed opioid agonists/antagonists dosage forms today.

Rivastigmine, an anti-Alzheimer’s drug, is effective in the treatment of mild to moderate dementia. Oral immediate release (IR) formulation suffers from limitation like severe GI adverse effects which may even result in treatment interruption, like vomiting, diarrhea and anorexia resulting in wide fluctuations in drug plasma levels and calling for altered frequency of dosing. Even the Novel Dru...

The present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. The obtained microcapsules were discrete, spherical with free flowing properties and ...

The present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. The obtained microcapsules were discrete, spherical with free flowing properties and ...