a major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. if the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. although some approaches are available for enhancing the diss...

acrylic-type polymeric systems having degradable ester bonds linked to ibuprofen were synthesized and evaluated as materials for drug delivery. ibuprofen, as a non-steroidal anti-inflammatory drug, was linked to 2-hydroxyethyl methacrylate by activated ester methodology in one-pot procedure. the resulting methacrylic derivative of ibuprofen was copolymerized with 2-hydroxyethyl methacrylate and...