In our societies, the proportions of elderly people and of obese individuals are increasing. Both factors are associated with high health-related costs. During obesity, many authors suggest that it is a high chronic intake of added sugars (HCIAS) that triggers the shift towards pathology. However, the majority of studies were performed in young subjects and only a few were interested in the int...

Angiotensin II (Ang II) plays important roles in ageing-related disorders through its type 1 receptor (AT1 R). However, the role and underlying mechanisms of AT1R in ageing-related vascular degeneration are not well understood. In this study, 40 ageing rats were randomly divided into two groups: ageing group which received no treatment (ageing control), and valsartan group which took valsartan ...

1. Classic evolutionary models interpret ageing as a cost of reproduction, but evolutionary research has thus far largely neglected the conceptual links between the evolution of ageing and a key mode of selection on male and female reproductive strategies – sexual selection and sexual conflict. 2. We synthesize ideas and evidence linking sex and ageing, and make the case that a focus on this fa...

Policies and programs designed to support ‘ageing well’ represent a key plank in government and community responses to the challenges of population ageing (1-3). Supporting ageing well might be defined as “the process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age” (3 p.12). This is a broad goal, touching on virtually all the...

Positive ageing and other related terms (optimal, healthy, successful, active, productive ageing) are viewed as scientific concepts, most of them operationally described by a broad set of bio-psycho-social factors, assessed through objective and subjective indicators, as well as being closely related to lay concepts reported cross-culturally by older persons. From a semantic perspective most of...

The story of vascular ageing was first described in the seventeenth century when Thomas Sydenham wrote that ‘A man is as old as his arteries’. This aphorism was returned to publicity lately when Peter Nilsson reintroduced the concept of early vascular ageing. As vascular ageing is described a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modificat...

The Large-Scale Integrating Project MARK-AGE (“European Study to Establish Biomarkers of Human Ageing”; www.mark-age.eu) was launched in April 2008 and is carried out by 26 research groups from academia, SMEs and industry. The scientific background is the following: The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related ...

The combined effects of electron-beam irradiation and ageing of beef were examined. The irradiated samples at dose of 0 or 2 kGy were kept and analyzed for the microbial growth, shear values, meat color, and nucleotide-related flavor compounds at different ageing temperatures (2, 10, or 25℃) for 8 d. The irradiation effect on inactivation of foodborne pathogens was also investigated. The popula...

A challenge in automatic speaker verification is to create a system that is robust to the effects of vocal ageing. To observe the ageing effect, a speaker’s voice must be analysed over a period of time, over which, variation in the quality of the voice samples is likely to be encountered. Thus, in dealing with the ageing problem, the related issue of quality must also be addressed. We present a...

AIM This paper reports a study whose aims were to introduce the theory of gerotranscendence to a group of older people; to give participants in the group an opportunity to discuss their ageing process; to study how participants described their ageing in relation to the theory; and to gather participants' opinions about discussing their ageing in a group. BACKGROUND The theory of gerotranscend...