Background Congenital hypothyroidism (CH) is one of the most common causes of mental disability, which can be prevented in the case of early diagnosis and treatment. We aimed to study the some relevant risk factors for CH in neonates born in Khorasan Razavi Province, Iran. Materials and Methods: This was a population-based case-control study conducted on 97,380 neonates.The study population c...

The rarity of consanguineous marriage in much of the industrialized world, and the current restriction or outright prohibition of first-cousin unions in a majority of US states and in East Asian countries such as China, North and South Korea and the Philippines, has led many commentators to overlook the fact that the Out-of-Africa migration some 60,000–70,000 years ago had been undertaken by qu...

Neonatal hearing loss is the most frequent sensorial congenital defect in newborns. No data are available on worldwide prevalence of congenital deafness. World Health Organization (WHO) data indicate 1-4 cases per 1000 individuals, with a considerable increase in developing countries. A prevalence exceeding 1 per 1000 however, indicates a serious public health problem calling for urgent attenti...

objectives: hearing loss (hl) is the most common sensory disorder, and affects 1 in 1000 newborns. about 50% of hl is due to genetics and 70% of them are non-syndromic with a recessive pattern of inheritance. up to now, more than 50 genes have been detected which are responsible for autosomal recessive non-syndromic hearing loss, (arnshl). in  iran, hl is one of the most common disabilities due...

a total of 8641 married couples were investigated from 28 iranian populations for consanguineous marriages and coefficient of inbreeding. the results showed considerable differences in the rate and kind of consanguineous matings among the various urban, rural, tribal, and religious populations studied. the observed frequencies of the consanguineous matings in the populations of iran are higher ...

Aims and Objectives: The objective of the present study is to assess the genetic composition of the two subgroups of Salis and the extent of genetic differentiation among them with the help of various demographic and genetic variables. Materials and Methods: A total of 520 couples belonging to two sub-groups namely, Padmasalis and Pattusalis residing in and around Visakhapatnam and Vizianagaram...

BACKGROUND To date, 5 well-confirmed genes for Parkinson disease (PD) have been identified, including 3 autosomal recessive genes: PTEN-induced putative kinase 1 (PINK1), parkin, and DJ-1. Almost nothing is known about the genetics of PD in Saudi Arabia; however, consanguineous families, not infrequent in this population, could be important in the evaluation of known PD genes and the search for...

Consanguineous marriages are respected and practiced among more than one billion of the world’s populationwith consanguinity rates reaching 20–50%. Consanguinity increases risk congenital anomalies, autosomalrecessive disorders, perinatal antenatal morbidities. This study determines knowledge regardingconsanguineous its genetic effects young adults.Objectives: 1. To assess regarding consanguine...

Children of consanguineous unions carry long runs homozygosity (ROH) in their genomes, due to parents' recent shared ancestry. This increases the burden recessive disease populations with high levels consanguinity and has been heavily studied some groups. However, there little investigation broader effect on patterns genetic variation a global scale. study, which collected published data inform...