Amyloidosis is a relatively rare disease that may be underdiagnosed and could affect the entire human body. Many organs may be affected, which could increase the morbidity and mortality. Cardiac involvement is the leading cause of poor prognosis. Patients with cardiac amyloidosis are usually admitted with heart failure. The clinical presentation varies greatly, and using the correct approach is...

INTRODUCTION Normal bacterial flora may be altered by a variety of factors. OBJECTIVE To study the aerobic bacterial conjunctival flora in patients with diabetes mellitus and to find its clinical significance by comparing the results to the conjunctival flora of non-diabetic subjects. MATERIALS AND METHODS A total of 75 diabetic patients were included as cases and 25 nondiabetics as control...

A 54-year-old man with polycystic liver disease received a domino liver transplantation (DLT) from a patient of hereditary ATTR amyloidosis with the transthyretin Ser50Arg mutation. Ten years after transplantation, he felt a slight numbness in his toes, and cardiac amyloidosis was simultaneously suspected upon a heart function evaluation. Biopsy specimens from the myocardium revealed transthyre...

Amyloidosis is a benign, slowly progressive condition characterized by the presence of extracellular fibrillar proteins in a variety of organs and tissues. It can be categorized as systemic or localized. Head and neck involvement can be seen in both systemic and localized amyloidosis. Systemic amyloidosis results in involvement of many organs, and shortens life expectancy, whereas localized amy...

Amyloidosis is a disorder of protein metabolism which is characterized by deposition of eosinophilic material intercellularly which has characteristic ultra-structural morphology and biochemical features. Amyloidosis may be primary but more often it is secondary to various inflammatory, neoplastic and suppurative conditions. Inflammatory bowel disease is an unusual cause for secondary amyloidos...

we are describing a new surgical approach in the management of advanced ocular surface cicatrization through a single procedure conjunctival-limbal-corneal allograft in which the external eye is resurfaced it involves a lamellar corneolimbal keratoplasty, 360° limbal stem cell transfer (on a “bipedicle” conjunctival-corneal carrier), and conjunctival tissue transplantation - all in a single con...

Amyloidosis is a rare disease with an incidence of approximately 6–10 cases per million person years. It is defined as tissue deposition of fibrils consisting of different types and weight of normal serum proteins’ subunits. Amyloidosis disease can involve different organs depending on the subtype. Amyloidosis frequently affects the heart, kidneys, gastrointestinal organs and nervous system. Am...

Introduction Systemic reactive (AA) amyloidosis represents the most important complication within TNF receptor associated periodic syndrome (TRAPS), familial Mediterranean fever (FMF) and other autoinflammatory syndromes, progressively leading to endstage renal failure. The homozygous condition of the serum amyloid A (SAA) variant SAA1.1 is significantly associated with the occurrence of AA amy...

CONTEXT Pancreatic involvement in systemic light chain (AL)-amyloidosis is exceedingly rare. Prior reports of endoscopic ultrasound (EUS) for the diagnosis of amyloidosis are also limited. CASE REPORT We report the first description of EUS-guided fine needle aspiration (FNA) for the diagnosis of primary AL-amyloidosis involving the pancreas. CONCLUSION EUS-FNA can be effectively utilized fo...