Objectives. The aim of the study was to investigate whether the use of the antifolate antibiotic trimethoprim during the 12 weeks before conception was associated with congenital malformations. Methods. We conducted a nationwide register-based cohort study including all Danish women giving birth from 1997 to 2004. All women with at least one prescription of trimethoprim dispensed during the 12 ...

background: to determine the prevalence and characteristics of birth defects in perinatal infants in hubei province during 200l-2008. methods: the prevalence of birth defects in perinatal infants delivered after 28 weeks or more was analyzed in hubei surveillance hospitals during 200l-2008. results: the incidence of birth defects in perinatal infants from 200l to 2008 was 120.0 per 10,000 birth...

INTRODUCTION Aortopulmonary collateral arteries are an uncommon variant of alternative blood supply in cases of complex congenital heart disease. Although surgery may still be the classic approach for this condition, mini-invasive endovascular occlusion has been recently attempted as an alternative less traumatic procedure. Children born to women with epilepsy are at increased risk of congenita...

It is generally believed that the incidence of congenital malformation of the heart is raised in relatives of affected individuals. The evidence in support of this view consists mainly of isolated records of families with more than one affected member (Courter et al., 1948, refer to 63 reported cases), but a few examples have been noted in the course of investigations of large series of patient...

Dandy-Walker malformation is a rare congenital malformation, characterized by agenesis or hypoplasia of the cerebellar vermis, cystic dilatation 4th ventricle and enlargement posterior fossa. Postnatal hydrocephalus develops in approximately 70-90% patients. The relationship with postaxial polydactyl has been defined as possible autosomal recessive syndrome (OMIM 220220). Here, we present an in...