OBJECTIVE Our aim was to report our experience with office-based treatment of severe laryngeal papillomatosis with percutaneous injection of cidofovir in a case series of 5 patients. STUDY DESIGN AND SETTING We conducted a retrospective review of a case series in a tertiary academic care voice disorders clinic. Adult patients with papillomas of the vocal cords and anterior commissure received...

Dowling-Degos disease (DDD) is a rare autosomal dominant inherited pigmentary disorder of the flexures with a reticulate aspect and with presence of prominent comedone-like lesions and pitted scars. The diagnosis includes acanthosis nigricans as well as other reticulate pigmentary disorders classified into: dyschromatrosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DU...

Dowling Degos disease is characterised by hyperpigmented macules arranged in a reticulate pattern in the flexures. The rare hypopigmented variant shows characteristic acanthosis with antler like rete ridges but with pigment only at the tips of the rete ridges. We describe here a rare variant with coexistence of characteristic reticulate hyperpigmentation and hypopigmented macules, which has bee...

D. Adamová, G. Agakichiev, H. Appelshäuser, V. Belaga, P. Braun-Munzinger, R. Campagnolo, A. Castillo, A. Cherlin, S. Damjanović, T. Dietel, L. Dietrich, A. Drees , S. I. Esumi, K. Filimonov, K. Fomenko, Z. Fraenkel, C. Garabatos, P. Glässel, G. Hering, J. Holeczek, V. Kushpil, B. Lenkeit, W. Ludolphs, A. Maas, A. Maŕın, F. Messer , J. Milošević, A. Milov, D. Mískowiec, L. Musa, Yu. Panebrattse...

Hybridization plays an important role in the evolution of certain groups of organisms, adaptation to their environments, and diversification of their genomes. The evolutionary histories of such groups are reticulate, and methods for reconstructing them are still in their infancy and have limited applicability. We present a maximum likelihood method for inferring reticulate evolutionary historie...

We find pairs of solutions to a differential equation which is obtained as a special limit of a generalized spheroidal wave equation (this is also known as confluent Heun equation). One solution in each pair is given by a series of hypergeometric functions and converges for any finite value of the independent variable z, while the other is given by a series of modified Bessel functions and conv...

Phylogenetic networks can model reticulate evolutionary events such as hybridization, recombination, and horizontal gene transfer. However, reconstructing such networks is not trivial. Popular character-based methods are computationally inefficient, whereas distance-based methods cannot guarantee reconstruction accuracy because pairwise genetic distances only reflect partial information about a...