the traveling salesman problem (tsp) is the problem of finding the shortest tour through all the nodes that a salesman has to visit. the tsp is probably the most famous and extensively studied problem in the field of combinatorial optimization. because this problem is an np-hard problem, practical large-scale instances cannot be solved by exact algorithms within acceptable computational times. ...

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

Practical work on spoken language translation must pursue two types of efficiency: computational efficiency, and “language engineering” efficiency. This paper describes the design, implementation, and evaluation of the GPL-based framework for spoken language translation that addresses both of these goals. In this framework, computational grammars are written in GPL, an easy-to-use imperative pr...

in this paper, we propose an iterated greedy algorithm for solving the blocking flow shop scheduling problem with total flow time minimization objective. the steps of this algorithm are designed very efficient. for generating an initial solution, we develop an efficient constructive heuristic by modifying the best known neh algorithm. effectiveness of the proposed iterated greedy algorithm is t...

Abstract DCT (Discrete Cosine Transforms) and IDCT (Inverse Discrete Cosine Transforms) are widely used for digital signal and image processing. Computational efficiency of DCT and IDCT dominate the performance of processing. How to improve computational efficiency is still an interesting topic for many researchers. In this study, the multiple-level resolution DCT in which the subband decomposi...

background and objectives: pomegranate juice (pj) contains large particles that stick to evaporator walls causing off flavors in the concentrate due to burning. microfiltration is used to clarify pj. fouling is a limiting phenomenon that can prevent the industrialization of membrane clarification. changes in the geometry of the membrane module such as using baffles are useful to decrease this p...

in this paper, a high-order and conditionally stable stochastic difference scheme is proposed for the numerical solution of $rm ithat{o}$ stochastic advection diffusion equation with one dimensional white noise process. we applied a finite difference approximation of fourth-order for discretizing space spatial derivative of this equation. the main properties of deterministic difference schemes,...

efficiency of enzymes which are used in industrial or environmental applications is highly dependent on their thermal stability. in this study, the stability of dfpase has been evaluated after introducing disulfide bonds to the structure. the results obtained from a series of protein design software were subjected to molecular dynamics simulation at different temperature to test the performance...

  Performance evaluation of universities is an important issue between researchers. Classic data envelopment analysis (DEA) models with deterministic data have been used by many authors to measure efficiency of universities in different countries. However, DEA with stochastic data are, rarely used to measure efficiency of universities. In this paper, input oriented model in stochastic data env...