OBJECTIVE Although serotonin reuptake inhibitors (SRIs) are approved for the treatment of obsessive-compulsive disorder (OCD), most OCD patients who have received an adequate SRI trial continue to have clinically significant OCD symptoms. The purpose of this study was to examine the effects of augmenting SRIs with exposure and ritual prevention, an established cognitive-behavioral therapy (CBT)...

One of the core behavioral features associated with obsessive compulsive symptomatology is the inability to inhibit thoughts and/or behaviors. Neuroimaging studies have indicated abnormalities in frontostriatal and dorsolateral prefrontal - anterior cingulate circuits during inhibitory control in patients with obsessive compulsive disorder compared with controls. In the present study, task perf...

OBJECTIVE The co-occurrence of obsessive-compulsive disorder (OCD) in adult patients with schizophrenia has been increasingly recognized. However, the rate of OCD comorbidity in adolescent schizophrenia patients has yet to be systematically evaluated. METHOD The rate of DSM-IV OCD was evaluated in 50 adolescent inpatients with schizophrenia or schizoaffective disorder. The severity of schizop...

Introduction: Despite the common sociocultural background in the Arab world, considerable differences exist between its different countries. Aim of the Study: The study was conducted aiming at evaluating the impact of obsessive compulsive disorder on patients’ life in two relatively different Arab cultures and the implication of these cultures on OCD presentation and symptomatology. Subjects an...

The financial consequences of compulsive buying are obvious given the large amount of debt reported by compulsive buyers in many studies. Credit cards allow consumers to borrow money very easily in order to satisfy their desire to purchase. In two web-based experiments, we found that compulsive shoppers often overspent and were rarely influenced by price. Their overspending was partially mediat...

Objective: Recent studies on treating obsessive compulsive disorder (OCD) have investigated noninvasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) to improve patients’ impaired emotion and cognition. However, such experiments have yielded mixed results, especially with respect to cognition. This study aimed to investigate whethe...

Objective: The relationship between obsessive compulsive disorder and schizophrenia has been a matter of dispute for ages. This study aimed to investigate the differences between schizophrenia with obsessive compulsive symptoms (OCS) and schizophrenia without OCS in affecting positive and negative symptoms of schizophrenia.  Methods: Study participants comprised 30 patients with schizophr...

The purpose of the present study was to examine the moderation effect of the thought control strategies on relationship between obsessive compulsive symptoms and metacognitive beliefs. 180 female and 95 male participants whose ages difference between 18 and 52, responded demographic information questionnaire, Thought Control Questionnaire, Meta-Cognition Questionnaire30, Padua Inventory-Washing...

BACKGROUND This study sought to investigate the efficacy of duloxetine for the treatment of obsessive-compulsive disorder (DSM-IV). METHODS Twenty individuals were enrolled in a 17-week, open-label trial of duloxetine at Massachusetts General Hospital. Data were collected between March 2007 and September 2012. Study measures assessing obsessive-compulsive disorder symptoms, quality of life, d...

The aim of the present study was to investigate the effects of comorbid obsessive-compulsive symptoms on emotional perception and theory of mind (ToM) in patients with first-episode psychosis. Participants were 65 patients with non-affective first episode psychosis (FEP) and 47 healthy controls. The patient group was divided into two subgroups, those with (FEP+; n=38) and those without obsessiv...