Bone formation (osteogenesis) is a complex process in which cellular differentiation and the generation of mineralized organic matrix are synchronized to produce hybrid hierarchical architecture. To study mechanisms osteogenesis health disease, there great need for functional model systems that capture parallel, both processes. Stem cell-based organoids promising as functional, self-organizing ...

Introduction: Infected tibial non-union has always posed a challenge for orthopaedic surgeons. The primary aim of our study is to analyze the role Ilizarov circular ring fixation in infected tibia, assess osteogenesis, infection rates, bony union, and limb lengthening along with functional outcomes associated complications. Materials Methods: This observational was conducted at Department Ortho...

We report a unique case of unilateral cerebellar hypoplasia in a young Chinese girl with osteogenesis imperfecta type IV. Magnetic resonance imaging showed mild basilar invagination and impression. Although unilateral cerebellar hypoplasia and osteogenesis imperfecta may have been coincidental diagnoses, we propose possible mechanisms for unilateral cerebellar hypoplasia secondary to osteogenes...

To rescue the oxidative stress induced inhibition of osteogenesis, vitamin C (VC) was chemically modified onto three-dimensional graphene foams (3D GFs), then their regulation on osteogenesis of human bone marrow-derived mesenchymal stem cells (BM-MSCs) was studied. Combined action of VC + GF significantly decreased H2O2-induced oxidative stress, and rescued H2O2-inhibited cell viability, diffe...

one of the dangerous complications of cataract extractions is vitreous loss. the purpose of this stuy is to evaluate the incidence of vitreous loss and its sepuale while teaching residents at rasoul akram hospital in iran. this study has been conducted on existing records of 730 eyes which were subjectd to extracapsular cataract extractions by 3rd and 4th year, right handed resident of rasoul a...

Researchers believe that most cases of cleft lip and palate are caused by genetic environmental factors. Nevertheless, the exact cause was not found. Nevertheless there allegations condition has something to do with osteogenesis imperfecta heterozygous mutation COL1A2 formation triple helix DNA accompanied Tetralogy Fallot in children a maternal history catatonic schizophrenia followed use valp...

Esophageal motor and sensory disorders are relatively rare conditions in the general population and afflicted patients are often initially misdiagnosed as having gastroesophageal reflux disease. Tests for these disorders have imperfect gold standards and are adjuncts to sound diagnostic reasoning. Treatments are palliative and have not been rigorously evaluated for some disorders. Symptoms and ...