نتایج جستجو برای: complementing group 1 xrcc1 gene

تعداد نتایج: 4202903  

Journal: :Cancer 2006
Lin Cai Nai-Chieh Yuko You Hua Lu Li-Na Mu Qing-Yi Lu Shun-Zhang Yu Anh D Le James Marshall David Heber Zuo-Feng Zhang

BACKGROUND To the authors' knowledge, few studies have been conducted to date regarding dietary selenium and the potential gene-nutrient interactions with single-nucleotide polymorphisms (SNPs) in different pathways on the risk of esophageal cancer. METHODS The authors investigated the role of dietary selenium intake and its interplay with SNPs of the ALDH2 (glutamic acid [Glu] 487 lysine [Ly...

2017
Haihui Chen Mengxin Wu Guisheng Li Li Hua Shaojun Chen Haixin Huang

To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT).Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the SNP of the XRCC1 ...

Journal: :The Eurasian journal of medicine 2017
Hanan Fouad Dina Sabry Heba Morsi Hany Shehab Naglaa F Abuzaid

OBJECTIVE The objectives of this study were to evaluate the impact of two X-ray repair cross complementing 1 (XRCC1) gene polymorphisms (Arg194Trp and Arg399Gln) on the risk of development of colorectal cancer (CRC) and to assess the expression levels of microRNA-21 (miR-21) in CRC patients. MATERIALS AND METHODS A case-control cross sectional study was conducted on 50 CRC patients and 50 can...

2015
Nina A. Moor Inna A. Vasil'eva Rashid O. Anarbaev Alfred A. Antson Olga I. Lavrik

Base Excision Repair (BER) efficiently corrects the most common types of DNA damage in mammalian cells. Step-by-step coordination of BER is facilitated by multiple interactions between enzymes and accessory proteins involved. Here we characterize quantitatively a number of complexes formed by DNA polymerase β (Polβ), apurinic/apyrimidinic endonuclease 1 (APE1), poly(ADP-ribose) polymerase 1 (PA...

2011
Mei-Kim Ang Mihir R. Patel Xiao-Ying Yin Sneha Sundaram Karen Fritchie Ni Zhao Yufeng Liu Alex J. Freemerman Matthew D. Wilkerson Vonn Walter Mark C. Weissler William W. Shockley Marion E. Couch Adam M. Zanation Trevor Hackman Bhishamjit S. Chera Stephen L. Harris C. Ryan Miller Leigh B. Thorne Michele C. Hayward William K. Funkhouser Andrew F. Olshan Carol G. Shores Liza Makowski Neil Hayes

Purpose:We evaluated X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) protein in head and neck squamous cell carcinoma (HNSCC) patients in association with outcome. Experimental Design: XRCC1 protein expression was assessed by immunohistochemical (IHC) staining of pretreatment tissue samples in 138 consecutive HNSCC patients treated with surgery (n 1⁄4 31), radiati...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Mei-Kim Ang Mihir R Patel Xiao-Ying Yin Sneha Sundaram Karen Fritchie Ni Zhao Yufeng Liu Alex J Freemerman Matthew D Wilkerson Vonn Walter Mark C Weissler William W Shockley Marion E Couch Adam M Zanation Trevor Hackman Bhishamjit S Chera Stephen L Harris C Ryan Miller Leigh B Thorne Michele C Hayward William K Funkhouser Andrew F Olshan Carol G Shores Liza Makowski D Neil Hayes

PURPOSE We evaluated X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) protein in head and neck squamous cell carcinoma (HNSCC) patients in association with outcome. EXPERIMENTAL DESIGN XRCC1 protein expression was assessed by immunohistochemical (IHC) staining of pretreatment tissue samples in 138 consecutive HNSCC patients treated with surgery (n = 31), radiatio...

2012
Yong-Gang Wang Tian-Ying Zheng

Certain genetic variants associated with repair of DNA substantially increase the risk of cancer in carriers because of defined biochemical alterations caused by the polymorphisms. Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damage (Almeidaet al., 2007). One of the most important proteins...

2013
Liu Yi He Xiao-feng Lu Yun-tao Long Hao Song Ye Qi Song-tao

BACKGROUND The Arg399Gln polymorphism in the X-ray cross-complementing group 1 (XRCC1) had been implicated in cancer susceptibility. The previous published data on the association between XRCC1 Arg399Gln polymorphism and cancer risk remained controversial. METHODOLOGY/PRINCIPAL FINDINGS To derive a more precise estimation of the association between the XRCC1 Arg399Gln polymorphism and overall...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Jian-Ying Sun Chun-Yang Zhang Zhen-Jun Zhang Yan-Fang Dong An-Long Zhang Zhi-Wei Wang Xiao-Long Mei

OBJECTIVE Previous studies of the association between X-ray cross-complementing group 1 (XRCC1) gene polymorphisms and the gliomas risk have yielded conflicting results, and thus a meta-analysis was performed to provide a more accurate estimation. METHODS A computerized literature search of 5 electronic databases was conducted to identify the relevant studies. Fixed or random effect models we...

2016
Xiaohua Qian Hua Tan Jian Zhang Keqin Liu Tielin Yang Maode Wang Waldemar Debinskie Weilin Zhao Michael D. Chan Xiaobo Zhou

The diagnosis for pseudoprogression (PsP) and true tumor progression (TTP) of GBM is a challenging task in clinical practices. The purpose of this study is to identify potential genetic biomarkers associated with PsP and TTP based on the clinical records, longitudinal imaging features, and genomics data. We are the first to introduce the radiogenomics approach to identify candidate genes for Ps...

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