نتایج جستجو برای: complement dependent lymphocytotoxicity cdc
تعداد نتایج: 759890 فیلتر نتایج به سال:
As platforms for therapeutic agents, monoclonal antibodies (MAbs) have already been approved, and several MAbs have demonstrated clinical effectiveness in a variety of malignancies. However, several issues have also been emerging in antibody therapy, such as high cost and insufficient drug action. Recently, to improve MAb activity in humans, effector functions have been subjects of focus, espec...
BACKGROUND Rituximab is used in the treatment of CD20+ B cell lymphomas and other B cell lymphoproliferative disorders. Its clinical efficacy might be further improved by combinations with other drugs such as statins that inhibit cholesterol synthesis and show promising antilymphoma effects. The objective of this study was to evaluate the influence of statins on rituximab-induced killing of B c...
Sandra L. Nehlsen-Cannarella, PhD, Loma Linda University Medical Center, Immunology Center, Loma Linda, CA 92354 (USA) Dear Sir, I read with interest the article by Stefoni et al. [1] published in your journal. One must applaud these authors on the magnitude of work required of such an endeavor. Promotion of long-term organ graft survival is the goal of every transplantation team, and so the de...
Effective treatment of high-risk neuroblastoma (NB) remains a major challenge in pediatric oncology. Human/mouse chimeric monoclonal anti-GD2 antibody (mAb) ch14.18 is emerging as a treatment option to improve outcome. After establishing a production process in Chinese hamster ovary (CHO) cells, ch14.18/CHO was made available in Europe for clinical trials. Here, we describe validated functional...
Dynamic consolidation of Virtual Machines (VMs) can effectively enhance the resource utilization and energyefficiency of the Cloud Data Centers (CDC). Existing research on Cloud resource reservation and scheduling signify that Cloud Service Users (CSUs) can play a crucial role in improving the resource utilization by providing valuable information to Cloud service providers. However, utilizatio...
OBJECTIVES To characterize the in vitro binding and effector function properties of CD20-directed small modular immunopharmaceutical (SMIP) 2LM20-4, and to compare its in vivo B-cell depletion activity with the mutated 2LM20-4 P331S [no in vitro complement-dependent cytotoxicity (CDC)] and rituximab in cynomolgus monkeys. METHODS Direct binding is examined in flow cytometry, confocal microsco...
In addition to Ag recognition, some Abs are capable of killing target organisms in the absence of phagocytes and complement. In this study, we report that an anti-Pseudomonas aeruginosa O6ad LPS IgG 1 , tobacco-expressed human S20 IgG 1 (te-hS20), as well as its recombinant Fab and single-chain variable fragment (scFv) fragments have cellular-and complement-independent bactericidal activity. te...
Purpose: Ofatumumab is an anti-CD20 antibody recently approved for treatment of fludarabine and alemtuzumab refractory chronic lymphocytic leukemia (CLL); it mediates much stronger complementdependent cytotoxicity (CDC) than rituximab. Human CD59, a key membrane complement regulator that inhibits CDC, is highly expressed in B-cellmalignancies and its upregulation is an important determinant of ...
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