he future of healthcare delivery systems will depend on heir ability to provide the best care at the least cost. In he clinical laboratory, this translates to ensuring that lecreased test use means appropriate use. The latter is nhikely to occur unless clinical laboratories provide practicing physicians with advice on test strategy and iterpretation of results. Effective clinical laboratory con...

Testing is the process of stimulating a system with inputs in order to reveal hidden parts of the system state. We consider a variant of the testing problem that was put forward in the model-based diagnosis literature, and consists of finding input patterns that definitely discriminate between different constraint-based system models. We show that this problem can be framed as a game played bet...

PURPOSE Minimal-risk randomized trials that can be embedded in practice could facilitate learning health-care systems. A cluster-randomized design was proposed to compare treatment strategies by assigning clusters (eg, providers) to "favor" a particular drug, with providers retaining autonomy for specific patients. Patient informed consent might be waived, broadening inclusion. However, it is n...

The purpose of this paper is to show that for a dense G set of three smooth convex bodies with nowhere vanishing curvature in the C topology k the open billiard obtained from these convex bod ies determines a potential the one that de nes the natural escape measure of this billiard which is non lattice This result generalizes one of the results obtained in a previous work of A Lopes and R Marka...

Scholars have been investigating the quick emergence of digital platforms, essentially through the lens of digital native firms. If there is limited occurrence of platforms launched by incumbent firms such as Daimler (Car2Go, Moovel) or Johnson Controls (Panopix), the economics of their strategic responses through platforms by incumbents merit attention. This paper provides the first largescale...

aces in the audience on the 25th of January! "How to win a house job" is not a subject to which there is a short answer, but rather one in which the importance lies ln the summation of a lot of minor points plus a few more major and more definite ?nes, so I shall give a general factual background and then some more detailed advice. The factual background I decided to obtain from a questionnaire...

Revealed comparative advantage indices are calculated for China (1980-2000 period) and the Chinese provinces (1990-1998 period) and then incorporated into a reduced form export equation. The results of China’s export patterns show that China has moved from a heavy industry-oriented development strategy to a comparative advantage one, with, however, marked differences among provinces. The econom...

With the availability of whole-genome sequences for an increasing number of species, we are now faced with the challenge of decoding the information contained within these DNA sequences. Comparative analysis of DNA sequences from multiple species at varying evolutionary distances is a powerful approach for identifying coding and functional noncoding sequences, as well as sequences that are uniq...

Techniques for the quantitation of proteins and peptides by mass spectrometry (MS) are reviewed. A range of labeling processes is discussed, including metabolic, enzymatic, and chemical labeling, and techniques that can be employed for comparative and absolute quantitation are presented. Advantages and drawbacks of the techniques are discussed, and suggestions for the appropriate uses of the me...

How can accountability be institutionalized across complex governance networks that are dealing with the transboundary pollution problem of mitigating greenhouse gas emissions at multiple spatial, temporal and social scales? To address this question, we propose an accountability framework that enables comparison of the democratic, market and administrative anchorage of actor accountability with...