Identifying the disulfide bonding pattern in a protein is critical to understanding its structure and function. At the state-of-the-art, a large number of computational strategies have been proposed that predict the disulfide bonding pattern using sequence-level information. Recent past has also seen a spurt in the use of Mass spectrometric (MS) methods in proteomics. Mass spectrometrybased ana...

background: transforming growth factor-beta (tgf-β) activation appears to be crucial for tissue injury in diabetic nephropathy (dn). fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent tgf-β modulator. in this study, the therapeutic effects of fibromodulin in the kidneys of streptozotocin (stz)-induced diabetic rats were investigated. methods: diabetic rats rec...

esophagus cancer is the eighth most common cancer worldwide and particularly high in an area extending from the southern border of the caspian sea in iran across central asia to china. since information about this mysterious disease is poor, proteomics may be solving this enigma. altering gene expression in cancer cell is a remarkable indicator can be detected by proteomics techniques and bioin...

endometriosis is a painful reproductive disease afflicting about up to 20% of women. it is one of the most frequent benign gynaecological diseases, however, little is known about the pathological of endometriosis. over the past decade, high-throughput proteomics technologies have evolved considerably and have become increasingly more commonly applied to the investigation of female reproductive ...