Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major world disease, with approximately 9 million new cases each year. Identification and treatment of active disease are essential for TB control. Serology may offer increased detection of active disease in patients with a positive tuberculin skin test (TST) or QuantiFERON-TB (QFT-G). The InBios Active TbDetect immunoglobulin G (...

Process development and optimisation studies for the manufacturing process of N-methyl paroxetine was done by applying Quality by Design (QbD) principles. A normal operating range was defined for each process parameter by technique of design of experiments and knowledge of process chemistry to ensure consistent high quality of advanced intermediate and control of impurities. Initial challenges ...

Reducing the number of host-vector interactions is an effective way to reduce the spread of vector-borne diseases. Repellents are widely used to protect humans from a variety of protozoans, viruses, and nematodes. DEET (N,N-Diethyl-meta-toluamide), a safe and effective repellent, was developed during World War II. Fear of possible side effects of DEET has created a large market for "natural" DE...

objective(s): fasting during the month of ramadan is a religious obligation and belief for healthy adult muslims. the aim of the present study was to determine the effects of ramadan fasting and physical activity on ‘blood hematological-biochemical parameters’.   materials and methods: in this study, twenty-six healthy males in two experimental groups were compared in two different instances be...

BACKGROUND Active vitamin B12 absorption is followed by an increase in holotranscobalamin (holoTC) upon loading with a high physiological dose of the vitamin (the CobaSorb test). This study evaluates the use of a newly launched EIA kit for measurement of holoTC (active B12) in relation to the CobaSorb test. METHODS Intra-assay imprecision and linearity of the EIA kit was examined, employing s...

an efficient procedure is presented for the evaluation of solid oxide fuel cell (sofc) anode microstructure triple phase boundary length (tpbl). triple phase boundary- the one that is common between three phases of the microstructure- has a great influence on the overall efficiency of sofc because all electrochemical reactions of anode take place in its vicinity. therefore, evaluation of tpbl f...

This study investigates relationships between congestion and travel time performance metrics crashes on road segments. The focuses work zone routes in Iowa, utilizing 2021 commercially-available probe vehicle data crash data. Travel were derived from the data, counts obtained Additional variables included characteristics (traffic volume, type, segment length) a categorical variable for presence...

Commercially available 4H-SiC substrate quality has improved over time, and this extensively reduced defect concentration in the active epitaxial layer, during epi growth conditions at interface. The objective of work is to investigate bulk crystal for purpose future vertical power device fabrication exfoliated, non-epitaxial, undoped material layers. Mathematical estimations on yield fraction,...

8β-Hydroxy-9(11),13-abietadien-12-one (1), an abietane diterpenoid and aryl hydrocarbon receptor (AhR) ligand, was synthesized in six steps from commercially available (+)-dehydroabietylamine (2). We used the hypervalent iodine catalyst phenyliodine dicarboxylate, a safer alternative to toxic organoselenide reagents, for oxidative dearomatization of ferruginol (7) compound 1. Compounds 1 2, as ...

Active mounts are desirable for isolating spacecraft science instruments from onboard vibrational sources such as motors and release mechanisms. Such active isolation mounts typically employ multilayer piezoelectric actuators to cancel these vibrational disturbances. The actuators selected for spacecraft systems must consume minimal power while exhibiting displacements of 5 to 10 μm under load....