BACKGROUND Substantial efforts over the past decade have increased rates of intravenous tissue plasminogen activator (tPA) use in the United States. We sought to determine changes in patient characteristics and rates of tPA use over time among hospitalized acute ischemic stroke (AIS) patients. METHODS AND RESULTS We analyzed all AIS patients (n=1 093 895) and those arriving ≤ 2 hours and trea...

Syphilis is a systemic sexually transmitted disease caused by Treponema pallidum ssp. pallidum (TPA). The origin and genetic background of Chinese TPA strains remain unclear. We identified a total of 329 single-nucleotide variants (SNVs) in eight Chinese TPA strains using next-generation sequencing. All of the TPA strains were clustered into three lineages, and Chinese TPA strains were grouped ...

12-O-Tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, induced phenotypic differentiation in the human thymic acute lymphocytic leukemia cell line, HPB-ALL. Within 30 min of seeding in the presence of TPA, the cells formed a smooth round shape. After a 7-day exposure to TPA, most of the cells became smaller and reminiscent of large or atypical lymphocytes. Electron microscopic ana...

Genomic mining revealed one major nonribosomal peptide synthetase (NRPS) phylogenetic cluster in 12 marine sponge species, one ascidian, an actinobacterial isolate and seawater. Phylogenetic analysis predicts its taxonomic affiliation to the actinomycetes and hydroxy-phenyl-glycine as a likely substrate. Additionally, a phylogenetically distinct NRPS gene cluster was discovered in the microbial...

Abstract A tabletop Two Photon Absorption-Transient Current Technique (TPA-TCT) set-up built at CERN was used to investigate a non-irradiated PIN diode, an irradiated and 5 × 5-multipad HPK LGAD. The intrinsic three dimensional spatial resolution of this method is demonstrated under normal incidence the laser probe. charge collection versus depth profile diode presented, where reflection on rea...

We provide a security analysis for full-state keyed Sponge and full-state Duplex constructions. Our results can be used for making a large class of Sponge-based authenticated encryption schemes more efficient by concurrent absorption of associated data and message blocks. In particular, we introduce and analyze a new variant of SpongeWrap with almost free authentication of associated data. The ...

We provide a security analysis for full-state keyed Sponge and full-state Duplex constructions. Our results can be used for making a large class of Sponge-based authenticated encryption schemes more efficient by concurrent absorption of associated data and message blocks. In particular, we introduce and analyze a new variant of SpongeWrap with almost free authentication of associated data. The ...

The growth dynamics and survival of the sponge Corticium candelabrum (Demospongiae: Homosclerophorida) were surveyed in the northwestern Mediterranean for more than 3 yr. Growth and regeneration rates, fission and fusion events and survival were monitored monthly. Moreover, in situ punctual clearance experiments were conducted seasonally searching for possible relationships between food uptake ...

UNLABELLED BACKGROUND NAD PURPOSE: Abnormalities in the fibrinolytic system have been associated with an increased risk for stroke in a few studies. This study was designed to test whether plasma levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), and tPA/PAI-1 complex could predict a first-ever stroke. METHODS The study was an incident case-control study ...