thought it might be of interest to note that during the peak of the outbreak in the hospitals of the area the usual alerts were sent out to all general practitioners, health visitors, and district nurses. Only two cases were reported from the community and confirmed at subsequent examination. However, in the old people's homes for which I was responsible nearly 15% of the residents were affecte...

Ionic detergents reduce electrostatic charge on plastic spacers, thereby improving in vitro drug delivery. The aim of this study was to gain practical information on the use of detergents and to evaluate the relevance of this information on in vivo drug deposition. Measurement of electrostatic charge and salbutamol particle size distribution was carried out on detergent-coated and noncoated pla...

Affinity tags such as polyhistidine greatly facilitate recombinant protein production. The solubility of integral membrane proteins is maintained by the formation of protein-detergent complexes (PDCs), with detergent present at concentration above its critical micelle concentration (CMC). Removal of the affinity tag necessitates inclusion of an engineered protease cleavage site. A commonly util...