نتایج جستجو برای: combined antineoplastic agents
تعداد نتایج: 722313 فیلتر نتایج به سال:
Lung, prostate, and stomach cancer are the most prevalent cancers among males. Breast, colon, cervical women. The literature also shows that patients suffering from increasing constantly, hence number of different chemotherapy treatments administered is increasing. main objective this review article to summarize effect age on half-life some antineoplastic drugs belonging category Topoisomerase ...
Does the administration of antioxidants during cancer chemotherapy affect antineoplastic efficacy or the development of side effects? Although the majority of preclinical studies involving the use of in vitro systems and animal models support the contention that certain antioxidants are of benefit, few clinical studies have been done (1,2). Factors to consider in the design of studies to answer...
Conventional chemotherapeutics and targeted antineoplastic agents have been developed based on the simplistic notion that cancer constitutes a cell-autonomous genetic or epigenetic disease. However, it is becoming clear that many of the available anticancer drugs that have collectively saved millions of life-years mediate therapeutic effects by eliciting de novo or reactivating pre-existing tum...
Antineoplastic drugs can be associated with several side effects, including cardiovascular toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX. Chemoterapeutic agents can alter redox homeostasis by increasing the production of reactive oxygen species (ROS) and reactive nitrogen species RNS. Cellular sources of ROS/RNS are cardiomyocytes, endothelial cells, stromal and...
Deoxyribonucleic acid (DNA) is an important molecular target for anti-cancer agents due to its involvement in gene expression and protein synthesis which are fundamental steps in cell division and growth. A number of antineoplastic agents interfere with DNA and hence disturb the cell cycle. Compounds including planar aromatic rings are privileged scaffolds in binding to the DNA. This characteri...
The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their ability to induce tumor cell apoptosis while sparing most normal tissues. Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the unstructured loop of Bcl-xL, and we demonstrate that deamidation of these aspar...
Despite the significant progress in anticancer drug development over recent years, there is a vital need for newer agents with unique, but still effective, mechanisms of action order to treat disease, particularly highly aggressive and drug-resistant types. Alkylating agents, particular nitrogen-based alkylators, are commonly used hematological solid malignancies; they exert their antineoplasti...
The effect of various classes of differentiation-inducing agents on macromolecular synthesis was studied in a human myeloblastic leukemia cell line (ML-1). Antineoplastic drugs such as 1-beta-D-arabinofuranosylcytosine, daunorubicin, and actinomycin D caused early inhibition of DNA synthesis, which generally preceded the accrual of differentiation markers. In contrast, retinoic acid and conditi...
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