Aberrant activation of Wnt signaling caused by mutations in adenomatous polyposis coli (APC) or -catenin is a critical event in the development of human colorectal tumors. Wnt signaling stabilizes -catenin, which in turn associates with TCF/LEF family transcription factors, ultimately altering the expression of Wnt target genes. We have recently identified ICAT, a -catenin-interacting protein t...

Aberrant activation of Wnt signaling caused by mutations in adenomatous polyposis coli (APC) or beta-catenin is a critical event in the development of human colorectal tumors. Wnt signaling stabilizes beta-catenin, which in turn associates with TCF/LEF family transcription factors, ultimately altering the expression of Wnt target genes. We have recently identified ICAT, a beta-catenin-interacti...

Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype is referred to as oncogene addiction and has been clinically validated by anticancer therapies that specifically inhibit oncoproteins such as BCR-ABL, c-Kit, HER2, PDGFR, and EGFR. Identifying additional genes that are required for tumor maintenance may lead to new targets for anticancer drugs. Although...

Cathepsin B, a thiol protease, is involved in cancer metastasis. To clarify the role of cathepsin B in tumor progression in human colorectal cancer, the relationship between its activity, immunohistochemical staining, and clinical tumor progression was investigated. Cathepsin B activity in adenocarcinomas was significantly elevated compared with that in the tumor-bearing tissue. Furthermore, th...

The study of tumor biomarkers was gradually facilitated by the adoption of proteomic strategies due to less invasiveness and higher sensitivity. Colorectal cancer is one of the most commonly occurring cancers worldwide and its incidence has markedly increased in Korea. While the adoption of proteomic strategies facilitated the study of tumor bioma...

background: vascular endothelial growth factor (vegf) is a signal protein produced by cells that stimulates angiogenesis and increased vascular permeability. the prognostic value of vegf expression in colorectal cancer is unclear as shown by the discordant results still reported in the literature. this study was designed for the evaluation of vegf expression and correlation with clinicopatholog...

Colorectal cancer is one of the most prevalent cancers in the world. It's survival expectancy depends on the time of diagnosis, stage and grade of the tumor, and general condition of the patient. Survival expectancy of this type of cancer reveals the quality of diagnostic and therapeutic services in the community. To improve and standardize the treatment modalities in this field, much resea...

Semaphorin-3F (SEMA3F) is a member of the class III semaphorin family, and is seen as a candidate tumor suppressor gene. The aims of this study were to evaluate the effect of SEMA3F in colorectal cancer (CRC) patients, and to explore the mechanism for that SEMA3F suppresses tumor progression and metastasis. The expression levels of SEMA3F in the colorectal cancer tissues and corresponding non-t...

background: cancer is the third most common cause of death in iran. colorectal cancer is an ideal tumor for screening. therefore, early diagnosis through screening can reduce its prevalence and mortality. on the other hand, knowledge of practitioners about screening programs has a direct relationship with their performance. methods: in the present cross-sectional-educational study, knowledge, a...

Objective: Colorectal cancer is one of the leading causes of cancer death in both developed and developing nations. Cathepsin D, a member of the aspartic protease family, induced by estrogen, was proved to be closely correlated with poor prognosis in breast cancer, but its role in colorectal cancer is not well established. We aimed in this study to evaluate the immunohistochemical expression of...