background: minimal bright red bleeding per rectum (mbrbpr) is a common complaint in adult patients. most studies have not been performed in patients with strictly minimal brbpr, and there are no evidence-based recommendations for this group of patients. materials and methods: patients with complaints as small amounts of red blood after wiping or a few drops of blood in the toilet bowl after de...

background: the present study sought to investigate molecular evidence for association between the presence of herpes simplex virus (hsv), cytomegalovirus (cmv), and epstein-barr virus (ebv) in crc and colorectal polyp by using the pcr method in iran. methods: in this analytical case-control study, we selected 15 patients with crc, 20 patients with colorectal polyp, and 35 patients without mali...

background: some recent studies reported human epidermal growth factor receptor (her-2/neu) as a marker that can be used in immunological studies of colorectal carcinoma for predicting the prognosis and the treatment. therefore, we aimed to investigate the frequency of her-2 expression in patients with colorectal cancer, and explore the relationship between clinicopathological prognostic factor...

introducation: cancers are the third most common cause of death in iran. colorectal cancer is an ideal tumor for screening. therefore, early diagnosis through screening can reduce its prevalence and mortality. on the other hand, knowledge of practitioners about screening programs has a direct relationship with their performance. methods: in a cross-sectional-educational study, knowledge, attitu...

conclusions imp3 immunoreactivity was associated with poor differentiation of tumor yet not associated with tumor size depth of invasion or lymph node involvement. results immunoreactivity pattern of imp3 was cytoplasmic in different clinicopathologic findings. among different clinicopathologic findings, we found a statistical relationship between tumor differentiation and imp3 (p = 0.047); so ...

background: colorectal cancer (crc) is a common and lethal malignancy worldwide. the incident rate of crc is different in various geographica regions. crc is a multifactorial disease; the factors involved included dietary and genetic factors. p53 gene is the most important tumor suppressor gene which involved in many cancers. the mutation rate in exons 7 and 8 of p53 gene in crc was reported to...

background there is evidence of a possible etiological role of human papillomaviruses (hpvs) in the development of colorectal cancer. loss of p53 tumor suppressor gene function has been found in many malignancies and it can occur in a variety of ways, including gene mutation and interaction with the e6 protein of oncogenic hpvs. the objective of this study was to determine the prevalence of hpv...