Collective gatherings foster group cohesion through providing occasion for emotional sharing among participants. However, prior studies have failed to disentangle two processes that are involved in emotional sharing: 1) focusing shared attention on the same emotion-eliciting event and 2) actively sharing one's experiences and disclosing one's feelings to others. To date, it has remained unteste...

Network analysts have debated the extent to which cohesion versus structural equivalence serves as a source of similar behavior among actors. More recently, role equivalence has emerged as an alternative to structural equivalence. Using data on the contribution patterns of corporate political action committees, I examine the effect of various indicators of cohesion, structural equivalence, and ...

Chromosome segregation in meiosis is controlled by a conserved pathway that culminates in Separase-mediated cleavage of the α-kleisin Rec8, leading to dissolution of cohesin rings. Drosophila has no gene encoding Rec8, and the absence of a known Separase target raises the question of whether Separase and its regulator Securin (Pim in Drosophila) are important in Drosophila meiosis. Here, we inv...

High cohesion, or module strength, indicates that a system has been well partitioned into components which have strong internal relationships. An understanding of cohesion is an important factor in software design. However, cohesion is difficult to define precisely and to quantify, particularly for object oriented (OO) software, and attempts to develop metrics have had limited success. We advoc...

Sister chromatid cohesion is essential for proper segregation of the genome in mitosis and meiosis. Central to this process is cohesin, a multi-protein complex conserved from yeast to human. Previous genetic studies in fungi have identified Pds5/BimD/Spo76 as an additional factor implicated in cohesion. Here we describe the biochemical and functional characterization of two Pds5-like proteins, ...

Eco1p/Ctf7p is an essential acetyltransferase required for the establishment of sister chromatid cohesion. Eco1p acetylates Smc3p and Mcd1p (Scc1p or Rad21p) to establish cohesion during S phase and in response to DNA damage, respectively. In addition to its acetyltransferase domain, Eco1p harbors a conserved zinc finger domain. The zinc finger has been implicated in the establishment of sister...

Although splicing is essential for the expression of most eukaryotic genes, inactivation of splicing factors causes specific defects in mitosis. The molecular cause of this defect is unknown. Here, we show that the spliceosome subunits SNW1 and PRPF8 are essential for sister chromatid cohesion in human cells. A transcriptome-wide analysis revealed that SNW1 or PRPF8 depletion affects the splici...

The equal distribution of chromosomes during mitosis is dependent on the maintenance of chromatid cohesion. This cohesion firmly tethers the sister chromatids of a replicated chromosome to one another until its two kinetochore regions, which lie on opposite sides of the centromere, acquire the proper bipolar attachment to the forming spindle. Then, shortly after the last kinetochore in the cell...

Centrosome cohesion, mostly regarded as a proteinaceous linker between parental centrioles, ensures that the interphase centrosome(s) function as a single microtubule-organizing center. Impairment of centrosome cohesion leads to the splitting of centrosomes. Although the list of cohesion proteins is growing, the precise composition and regulation of centrosome cohesion are still largely unknown...

OBJECTIVE Family rituals are associated with adaptive functioning in pediatric illness, including quality of life (QoL). This article explores the role of family cohesion and hope as mediators of this association in children with cancer and their parents. METHODS Portuguese children with cancer (N = 389), on- and off-treatment, and one of their parents completed self-report measures. Structur...