Polymorphisms of the p53 gene, which participates in DNA repair, can affect the functioning of the p53 protein. The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberrations in chronic hepatitis B patients. The present study aimed to examine the frequency of chromosom...

The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 Mexican women with endometriosis. The observed genotype frequenc...

BACKGROUND The final common pathway for open angle glaucoma (OAG) is retinal ganglion cell apoptosis. Polymorphisms in p53, a major regulator of apoptosis, affect the efficiency of cell death induction. Association studies of p53 haplotypes and OAG have had conflicting results. OBJECTIVE To examine the association between p53 haplotypes and OAG in a larger white population than in previous re...

background: human papillomavirus (hpv) and p53 alterations are speculated to play a role in carcinogenesis. this study was carried out to find out the association of hpv and p53 with precancerous lesions of the oral cavity such as leukoplakia: the objective of this study was to find the association among human papilloma virus (hpv) 16 infections and p53 polymorphism in tobacco using the oral le...