The mortality rate from snakebites in West Bengal is very high and most of the deaths are caused by the Daboia russelli and Naja naja envenomation. Twenty-three plants from the seventeen families were collected from the traditional healers and explored for the first time for antisnake venom activity. In our previous report, the methanolic root extract of the Indian medicinal plants Pluchea indi...

Naja sumatrana is the dominant cobra species in Malaysia, Singapore, Borneo, and Sumatra, and it does not have specific antivenom. The Haffkine antivenom has been advocated instead. This study aims to determine the efficacy of this antivenom against Naja sumatrana envenoming using a mouse model. Methods. Male Swiss albino mice were used. Intravenous LD50 was first determined separately for Naja...

The aim of this study was to evaluate the effect of venom from Naja naja karachiensis on platelet-poor plasma, activated partial thromboplastin time (aPTT), prothrombin time (PT) / international normalized ratio (INR), thrombin time (TT) and to evaluate its effect on clotting time upon storage of plasma for a specific time period with possible mechanism responsible for that. Prolongation of PT ...

Washed blood corpuscles of certain species of animals in a concentration of about (5) per cent suspended in salt solution containing above 4 per cent of cobra venom undergo changes in their resistance to certain physical and chemical agents. They become non-haemolyzable by water, ether, saponin, and quite strong solutions of lecithin, provided always that the excess of venom has not been entire...

Snakebite envenomations cause severe local tissue necrosis and the venom metalloproteinases are thought to be the key toxins involved. In this study, the ethanolic extract from seed kernels of Thai mango (Mangifera indica L. cv. 'Fahlun') (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent and dose-dependent inhibitory effects on the caseinolytic and fi...

Background: Celosia leptostachya belongs to Amaranthaceae plant family. Its leaves are used traditionally in the treatment of conditions, such as convulsion, eye infection and most notably cure snakebites. This study investigated inhibiting effect extract C. against cobra snake venom mice. Methods: We 36 albino mice mixed gender, weighing 20-25 g. They were divided into six groups rats each. Ea...

of the envenomation maybe both systematic and localized.5 Depending on the species of the snake involved and the amount of venom injected. Localized tissue damage is found to occur in many internal organs including the brain, lungs, heart, kidney, liver and endocrine glands.6,7 On the other hand, cobra venoms were reported to contain many active ingredients that beside neurotoxicity it can Khid...