نتایج جستجو برای: coagulation pathway
تعداد نتایج: 358621 فیلتر نتایج به سال:
During the past 20 years contributions from many laboratories have led to the development of isolation procedures, delineation of primary structures, and more recently, to the expression of recombinant proteins associated with the coagulation cascade. In general, studies of coagulation proteins under defined conditions have demonstrated the prescience of Davie and Ratnoff and MacFarlane in thei...
Chitosan was recently indicated to enhance osteogenesis, improve wound healing but to activate the coagulation and the complement systems. In the present study approximately 10 nm thick chitosan film were prepared on aminopropyltriethoxysilane (APTES) coated silicon. The surfaces were incubated in serum or plasma and subsequently in antibodies towards key complement and contact activation of co...
The mechanistic description of a biological process first involves the development of an inventory of constituents that are presumed essential for the expression of the function. Although initially based on pathology, more frequently this inventory is developed by in vitro tests on the biochemistry, cell biology, or molecular genetics of a process. Elaborate schemes describing physiological rea...
Selective inhibition of the intrinsic coagulation pathway is a promising strategy for developing safer anticoagulants that do not cause serious bleeding. Intrinsic tenase, the final and rate-limiting enzyme complex in the intrinsic coagulation pathway, is an attractive but less explored target for anticoagulants due to the lack of a pure selective inhibitor. Fucosylated glycosaminoglycan (FG), ...
The article published by Navarro et al1 in this issue of Revista Española de Cardiología reports the experience of 4 anticoagulation units located in large referral hospitals in Spain. The article also illustrates the appropriateness of monitoring treatment in specialist units to maintain the level of anticoagulation within the very narrow margin that allows prevention of thrombosis without cau...
The coagulation and immune systems, two vital systems in the human body, share intimate connections that fundamentally determine patient health. These work together through several common regulatory pathways, including Tissue Factor (TF) Pathway. Immune cells expressing TF producing pro-inflammatory cytokines can influence coagulation, while factors processes reciprocally impact responses by ac...
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