objective (s): transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. a novel testosterone transdermal delivery system (tdds) was developed using a palm oil base called hamintm (a commercial product) and tested using in vitro and in vi...

The dissolution from a liquid CO2 lake source located at a flat ocean bottom at 3,000 m depth is investigated. Using the unsteady, two-dimensional advection–diffusion equation, temporal and spatial distribution of CO2 dissolved from the source of 500 m length and of unit span is sought in a domain of 20 km horizontal and 200 m vertical extent. Different cases were run with uniform longitudinal ...

Hydrothermally stable particles of the metal-organic framework MIL-101(Cr) were incorporated into a polysulfone (PSF) matrix to produce mixed-matrix or composite membranes with excellent dispersion of MIL-101 particles and good adhesion within the polymer matrix. Pure gas (O2, N2, CO2 and CH4) permeation tests showed a significant increase of gas permeabilities of the mixed-matrix membranes wit...

Gas separation using porous solids have attracted great attention due to their energetic applications. There is an enormous economic and environmental interest in the development of improved technologies for relevant processes, such as H2 production, CO2 separation or O2 and N2 purification from air. New materials are needed for achieving major improvements. Crystalline materials, displaying un...

By using molecular dynamics simulation, the dynamic behaviors of particle permeation through a four-helix-bundle model channel are studied. The interior cavity of the four-helix-bundle provides the "routes" for particle permeation. The main structural properties of the model channel are similar to those that appear in natural four-helix-bundle proteins. It is found that the interior structure o...

To accelerate the commercial application of mixed-conducting membrane reactor for catalytic reaction processes, a robust mixed-conducting multichannel hollow fiber (MCMHF) membrane reactor was constructed and characterized in this work. The MCMHF membrane based on reduction-tolerant and CO2-stable SrFe0.8Nb0.2O3-δ (SFN) oxide not only possesses a good mechanical strength, but also has a high ox...

A triple-layer composite membrane with porous-dense-porous structure was proposed to develop a high performance membrane reactor. The triple-layer composite membrane consists of a porous Sr0.7Ba0.3Fe0.9Mo0.1O3 δ (SBFM) layer, a dense 0.5 wt% Nb2O5-doped SrCo0.8Fe0.2O3 δ (SCFNb) layer and a porous La0.8Sr0.2MnO3 δ–yttria stabilized zirconia (LSM/YSZ) layer. The porous layers can effectively redu...

Covalent organic frameworks (COF) have been gathering much attention because the shapes, sizes, and chemical functions of their nanostructured pores can be arbitrarily controlled by designing precursors. We fabricated cm-sized free-standing COF films with thickness 50–100 nm an alternating vacuum deposition polymerization method. Precise adjustment stoichiometry digitally was essential for prod...

High-temperature membranes for CO2 transport and separation has attracted significant interest from academia industries due to their potential mitigate the emissions of ultimately global warming/climate change. In this study, we report a dual-phase membrane fabricated porous proton conducting BaZr0.8Y0.2O3-δ (BZY) matrix eutectic mixture Li2CO3–Na2CO3 (denoted as MC). The exhibits high permeati...

The difficulty in characterizing ion conduction through membrane channels at the level of individual permeation events has made it challenging to elucidate the mechanistic principles underpinning this fundamental physiological process. Using long, all-atom simulations enabled by special-purpose hardware, we studied K(+) permeation across the KV1.2/2.1 voltage-gated potassium channel. At experim...