The analysis of the mutational landscape of cancer, including mutual exclusivity and co-occurrence of mutations, has been instrumental in studying the disease. We hypothesized that exploring the interplay between co-occurrence, mutual exclusivity, and functional interactions between genes will further improve our understanding of the disease and help to uncover new relations between cancer driv...

Today, SDL and SystemC are two very popular languages for embedded systems modeling. SDL has specific advanced features that make it good for reflection of the multi-object systems and interactions between modules. It is also good for system model validation. The SystemC models are better suitable for tracing internal functions of the modeled modules. The hypothetical possibility of combined us...

The emergence of pluripotent epiblast (EPI) and primitive endoderm (PrE) lineages within the inner cell mass (ICM) of the mouse blastocyst involves initial co-expression of lineage-associated markers followed by mutual exclusion and salt-and-pepper distribution of lineage-biased cells. Precisely how EPI and PrE cell fate commitment occurs is not entirely clear; however, previous studies in mice...

The differences in genetic backgrounds between deciduous and permanent teeth might contribute to the differences in developmental processes, histological characteristics, and tooth life cycles. Here, we attempted to identify significantly different modules between permanent and deciduous teeth via network and pathway analyses. We identified 291 differentially expressed genes (DEGs) between perm...

Modules and their Condition Specific Regulators from Gene Expression Data Eran Segal , Michael Shapira, Aviv Regev, Dana Pe’er David Botstein, Daphne Koller , Nir Friedman Much of a cell's activity is organized as a network of interacting modules: sets of genes co-regulated to respond to different conditions. We present a probabilistic method for discovering regulatory modules from gene express...

The HKR of racemic syn- or anti- alkoxy- and azido epoxides catalyzed by Co(salen) complex affords a practical access to a series of enantioenriched syn- or anti- alkoxy- and azido epoxides and the corresponding 1,2-diols. This strategy has been successfully employed in the concise, enantioselective synthesis of bioactive molecules such as (S,S)-reboxetine and (+)-epi-cytoxazone.