نتایج جستجو برای: cns tumors
تعداد نتایج: 279888 فیلتر نتایج به سال:
Background: Covalent inhibition of mutant KRAS G12C protein by locking this oncogenic driver in its inactive state is clinically efficacious. Sotorasib and adagrasib have improved overall response rates (ORR) progression-free survival (PFS) patients with G12C-mutant non-small cell lung cancer (NSCLC). However, achieving deeper more durable responses remain as challenges targeting G12C. Treatmen...
Abstract Pediatric patients with advanced relapsed/refractory (R/R) solid (including central nervous system [CNS]) tumors have poor prognoses. KIT alterations are common in germ cell and high-grade glioma (HGG); platelet-derived growth factor receptor alpha (PDGFRA) sarcoma HGG. Diffuse midline gliomas H3K27-altered (DMG-H3K27-altered) depend on PDGFRA signaling for tumor growth. However, no KI...
CNS Primitive Neuroectodermal tumors (CNS-PNETs) are members of the embryonal family of malignant childhood brain tumors, which remain refractory to current therapeutic treatments. Current paradigm of brain tumorigenesis implicates brain tumor-initiating cells (BTIC) in the onset of tumorigenesis and tumor maintenance. However, despite their significance, there is currently no comprehensive cha...
OBJECT Primitive neuroectodermal tumors of the central nervous system (CNS-PNET) arising in the brainstem are extremely rare, and knowledge about them is limited. The few existing case series report fatal outcomes. The purpose of this study was to analyze clinical characteristics of and outcome for brainstem CNS-PNET patients treated according to the consecutive, population-based HIT studies co...
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