BACKGROUND AND PURPOSE To reduce bleeding and damage to central nervous system tissue in intracerebral hemorrhage, the coagulant effect of thrombin is essential. However, thrombin itself can kill neurons in intracerebral hemorrhage as can the matrix metalloproteinases (MMPs), which are also elevated in this condition, in part due to thrombin-mediated activation of MMPs. It is thus important to ...

T hrombin is a key enzyme in hemostasis and thrombosis, regulating proand anticoagulant reactions by interacting with other coagulation proteins and cellular receptors. Thrombin also carries out a plethora of biologically relevant actions that link to other complex biological processes such as angiogenesis, inflammation, and cell proliferation. Thrombin is therefore likely to be involved in can...

The initiation phase of enzyme generation in a reconstituted model of the tissue factor (TF) pathway to thrombin was evaluated. At 1.25 pM added TF, no thrombin generation was observed in the absence of factor V. The substitution of factor Va for factor V increased the rate of thrombin generation. Factor X activation during the initiation phase was not influenced by the absence of factor VIII o...

the absence of cerebrospinal fluid (csf) pleocytosis in invasive meningococcal disease (imd) has been associated with an increased risk of death. it is unknown whether patients who lack a cellular response to central nervous system (cns) infection are at the same risk of adverse outcome as patiens without cns infection. to determine the frequency of presentation and outcome of three groups of c...

The last 15 years have seen an explosion of new findings on the role complement, a major arm immune system, in central nervous system (CNS) compartment including contributions to cell migration, elimination synapse during development, aberrant pruning neurologic disorders, damage nerve cells autoimmune diseases, and traumatic injury. Activation complement multiple sclerosis (MS) is typically th...

OBJECTIVE Thrombin, the final coagulation product of the coagulation cascade, has been demonstrated to have many physiological effects, including pro-fibrotic actions via protease-activated receptor (PAR)-1. Recent investigations have demonstrated that activation of the cardiac local coagulation system was associated with atrial fibrillation. However, the distribution of thrombin in the heart, ...

Exchange transfusion (ET) with adult blood is a standard procedure for neonates with severe hyperbilirubinemia. How ET affects newborn coagulation system remains, however, largely unknown. Thus, we prospectively evaluated the effect of ET on thrombin formation and coagulation profile in 18 newborns (22 ETs). Prothrombin fragment F1+2 and thrombin-antithrombin complexes increased considerably du...