Bovine leukemia virus (BLV) was investigated in the central nervous system (CNS) of cattle with neurological syndrome. A total of 269 CNS samples were submitted to nested-PCR (BLV env gene gp51), and the viral genotypes were identified. The nested-PCR was positive in 4.8% (13/269) CNS samples, with 2.7% (2/74) presenting at histological examination lesions of nonpurulent meningoencephalitis (NP...

INTRODUCTION Erdheim-Chester disease (ECD) is a rare, systemic form of non-Langerhans cell histiocytosis of the juvenile xanthogranuloma family with characteristic bilateral symmetrical long bone osteosclerosis, associated with xanthogranulomatous extra skeletal organ involvement. In ECD, central nervous system (CNS) and orbital lesions are frequent, and more than half of ECD pa tients carry th...

The unambiguous identification of oligodendrocytes in tissue sections, especially in myelinated tracts, is often difficult. Most of the antibodies used to identify oligodendrocytes label the myelin sheath as well. Originally described as an inhibitor of axonal outgrowth, Nogo-A is known to be strongly expressed in mature oligodendrocytes in vivo. In the present investigation we analyzed the exp...

Purpose: To report the clinical and neuroimaging, central nervous system (CNS) findings of patients with Fabry disease (FD) during 24 months of enzyme replacement therapy (ERT) with agalsidasealpha. Method: Eight patients were included. Six completed 24 months of ERT. Clinical and magnetic resonance imaging (MRI) data were obtained at 0, 12 and 24 months of ERT. White matter lesions (WML) were ...

Background: Intrauterine infections (TORCH) lead to the involvement of various organs of the body of the fetus, including the eye. The aim of this study was to determine the frequency and clinical response of eye lesions to specific drugs, in infants with confirmed TORCH induced ocular lesions. Methods: This historical cohort study from 2011 to 2017, had done in Pediatrics and Ophthalmology De...

BACKGROUND Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS), which is characterized by the presence of pathogenic serum autoantibodies against aquaporin 4 (AQP4) in the vast majority of patients. The contribution of T cells to the formation of astrocyte destructive lesions is currently unclear. However, active human NMO lesions contain CD4+...

Cavernous hemangiomas are uncommon vascular malformations of the CNS that may affect any part of the neuroaxis. Most of these lesions are intracranial; supratentorial sites are most common [1]. In the spine, lesions of the vertebral bodies are most common, intramedullary [2] and intradural extramedullary [3] lesions of the spinal axis are uncommon, and purely epidural lesions are rare [4, 5]. W...

Reliable biomarkers are needed to avoid diagnostic delay and its devastating effects in patients with primary central nervous system (CNS) lymphoma (PCNSL). We analysed the discriminating sensitivity specificity of myeloid differentiation response (88) (MYD88) L265P mutation (mut-MYD88) interleukin-10 (IL-10) cerebrospinal fluid (CSF) both newly diagnosed (n = 36) relapsed 27) PCNSL 162 control...

Abstract The receptor for colony stimulating factor 1 (CSF-1R) is important the survival and function of myeloid cells that mediate pathology during experimental autoimmune encephalomyelitis (EAE), an animal model multiple sclerosis (MS). CSF-1 IL-34, ligands CSF-1R, have similar bio-activities but distinct tissue context-dependent expression patterns, suggesting they different roles. This coul...

Cerebellar ataxic syndromes, although uncommon, have been reported previously in patients taking metronidazole. However, almost all cases describe instances where were prolonged or high doses of the drug. We report a 65-year-old man who consumed 400 mg metronidazole 3 times over 1 day and presented with slurring speech, imbalance while walking diplopia. The symptoms developed after consumption ...