The vast consequences associated with cytomegalovirus (CMV) infection poses an important public health problem and confers economic burden to society. Yet, despite its recognized importance and improvements in the present era of preemptive therapy, complete prevention of CMV continues to be challenging. Screening donated blood for CMV is neither customary nor mandatory, increasing the potential...

BACKGROUND Little is known about viral co-infections in African human immunodeficiency virus (HIV)-infected children. We examined the prevalence of seromarkers for cytomegalovirus (CMV), herpes simplex virus type 2 (HSV-2) and hepatitis B virus (HBV) infections among HIV-infected, antiretroviral treatment (ART)-naïve children in Lilongwe, Malawi. METHODS Ninety-one serum samples were tested f...

Objective To characterize T-cell receptors (TCRs) and identify target epitopes in multiple sclerosis (MS). Methods Peripheral blood mononuclear cells were obtained from 39 MS patients 19 healthy controls (HCs). TCR repertoires for α/β/δ/γ chains, diversity, V/J usage determined by next-generation sequencing. β chain compared with affectation status using a novel clustering method, Grouping of L...

Cytomegalovirus (CMV) infection in immunocompetent adults is usually asymptomatic, but results lifelong latency. Infection occurring congenitally or immunodeficiency can lead to cognitive impairment. We aimed investigate the associations between CMV exposure and intelligence quotient (IQ) patients with schizophrenia spectrum disorders (SZS), bipolar (BDS) healthy controls (HC). immunoglobulin G...

Cytomegalovirus (CMV) is the leading cause of viral-associated congenital infections. Moreover, it can also be acquired. Between 50 to 80 percent of the world’s population is seropositive for CMV and most clinical disease occurs in individuals previously infected with CMV. Rarely, serious CMV infection has occurred in individuals with healthy immune system. In contrast to immunocompetent patien...

cytomegalovirus (cmv) is a widespread pathogen that is found in milk, saliva, urine, cervical secretions, and semen fluid. it is supposed that cmv is a risk factor for breast cancer. the aim of this study was to determine the frequency of cmv among benign and malignant breast tumors. paraffin embedded breast carcinoma (n=24) and fibroadenoma (n=24) samples were collected from toos and firoozgar...