Introduction: Primaquine is one of the essential medicines used to treat malaria due Plasmodium vivax. acts by eradicating hypnozoites in liver, and its effect dependent on drug concentrations target tissue. The present study aimed prepare primaquine nanoparticle formulation using chitosan as carriers improve on-target delivery liver. Methods: Primaquine-loaded nanoparticles were prepared ionic...

Cefixime is a significant member of orally active third generation cephalosporin and has excellent activity against many pathogens. The virtual bioavailability of a newly industrial dispersible tablet as compared with a recognized identified formulation. An open-label, single-dose, randomized, 2-way crossover study was conducted in fasted healthy Iranian male volunteers. Eligible participa...

In this paper, the classic job shop scheduling problem of minimizing makespan, J//Cmax, is studied. A heuristic approach is presented for solving the J//Lmax problem using an iterative deterministic simulation technique combined with simulated annealing. A simple transformation is provided for converting a J//Cmax problem to an equivalent J//Lmax problem. The approach is tested on some well-kno...

In this crossover study in 12 healthy volunteers, coadministration of amprenavir (1,200 mg; single dose) with grapefruit juice slightly reduced the maximum concentration of drug in serum (Cmax) compared to administration with water (7.11 versus 9.10 microg/ml), slightly increased the time to Cmax (1.13 versus 0.75 h), and did not affect the area under the concentration-time curve from 0 to 12 h...

The bioavailability of a generic diclofenac sodium sustained release tablet preparation (Zolterol, SR) was compared with the innovator product, Voltaren, SR. Twelve healthy adult male volunteers participated in the study, which was conducted according to a randomized, two-way crossover design with a wash out period of one week. The bioavailability of diclofenac was compared using the parameters...

This work deals with the problem of scheduling n independent jobs on m unrelated parallel machines with the objective of minimizing the makespan (the total elapsed time from the start of execution until all jobs have been completed). Preemption is not allowed. This way a job, once assigned to a particular machine, may not be removed until it has finished its execution. All the machines start wo...

A high-pressure liquid chromatographic assay was developed for the detection of HR 810 in rabbit plasma. There was no interference in the high-pressure liquid chromatographic assay from other antibiotics. The method was accurate, reproducible, and capable of detecting less than 1 microgram of HR 810 per ml in plasma. The assay correlated with the microbiological assay (correlation coefficient, ...

The relative bioavailability of the test (generic) product 2 × 25 mg baclofen tablets, with respect to the reference product, Lioresal® 2 × 25 mg tablets (baclofen; Squibb) was determined in a single-blind, single dose, randomised, crossover study. The mean values for the variable Cmax were 737.6 ng/ml for the reference and 739.5 ng/ml for the test product. The mean values for the variable AUC ...

Background: Gold bhasma [Swarnabhasma] is a ancient Ayurvedic medicine used for rejuvenation and longevity. This preliminary attempt to study the bioavailability of this medicine. Objectives: It was aimed estimate comparative gold up five hours after oral dose with four different anupana. Materials methods: In in vivo study, 30 healthy human participants were allocated randomly into groups havi...

Event cameras are emerging vision sensors and their advantages suitable for various applications such as autonomous robots. Contrast maximization (CMax), which provides state‐of‐the‐art accuracy on motion estimation using events, may suffer from an overfitting problem called event collapse. Prior works computationally expensive or cannot alleviate the overfitting, undermines benefits of CMax fr...