The plasma level of factor VII activity was a risk factor for the development of ischemic heart disease (IHD) in a prospective epidemiological study of hemostatic factors. We have previously reported significant correlations between factor VII clotting activity or antigen and lipid fractions in a group of 132 young men (< 30 years old) at low risk for IHD and concluded that control of the plasm...

OBJECTIVE To assess the cost effectiveness of primary prophylaxis with clotting factor instead of treatment following a bleed (on-demand) for individuals with severe haemophilia. DESIGN Different data sources on the clinical effects and costs of treatments were combined using a Markov model. SETTING English treatment centres. PERSPECTIVE UK societal. PARTICIPANTS Hypothetical cohorts of...

In medicine, blood groups play an active role. A noticeable relationship is observed linking ABO with the Wilbrand factor and vWF deficiency which results in hemorrhagic disorders, while increased levels are a risk for clotting. Previous investigations found that individuals group O have long hemorrhageand clotting time. The aim of current study to evaluate bleeding time different sex also. Thi...

In the absence of vitamin K many mammals generate proteins (PIVKAs) which axe immunologically identical to the vitamin K-dependent clotting factors but which lack thet functional activity [1]. At the moment of their discovery in 1963 121 It was already supposed that PIVKAs were precursors of the vitamin K-dependent coagulation factors. After the discovery by Stenflo and coworkers [3] that the 7...

Egg white trypsin inhibitor activated coagulase clotting when added to a final concentration between 2 and 60 mg/ml. The greatest increase in clotting rate was observed in reaction mixtures containing the lowest concentrations of serum and plasma. Maximal activation was reached with 40 mg of trypsin inhibitor per ml when either serum or plasma was used as the source of coagulase-reacting factor...

The biochemical era of blood coagulation research begins toward the end of the 19th century, primarily with the work of Alexander Schmidt1 and Paul Morawitz,2 who hypothesized that the fundamental reactions involved in clotting included the activation of prothrombin to thrombin by thromboplastins and the conversion of fibrinogen to fibrin by thrombin. Throughout the first half of the twentieth ...

Levels of clotting factors II, V, and VII were measured on admission and then daily in 12 patients with grade IV hepatic coma due to fulminant hepatic failure. Factor VII levels obtained within 36 hours of the development of grade IV coma were not of value in predicting which patients would subsequently recover consciousness. Four of the latter group had levels below 9% at this time while the l...