To identify drugs that are potentially used for the treatment of COVID-19, potency 1403 FDA-approved were evaluated using a robust pseudovirus assay and candidates further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) Asenapine (hydrochloride), showed potent inhibitory effects in both virus The combination (hydrochloride...

I A T p d m c vulatory dysfunction is one of the most common causes of eproductive failure in sub-fertile and infertile couples. In the bsence of other significant infertility factors, successful vulation induction often will restore normal fertility. Cloiphene citrate (CC) is the best initial treatment for the large ajority of anovulatory infertile women. The first clinical rial of CC therapy ...

INTRODUCTION A heterotopic pregnancy is defined as the presence of a combined intrauterine and ectopic pregnancy. Its estimated incidence is accepted as between 1/7000 and 1/30,000 pregnancies. It is also reported to be as high as 1% after the use of assisted reproductive technology, but Clomiphene Citrate which increases the rate of twinning, could be associated with a heterotopic pregnancy ra...

background: unovulation is the most common cause of infertility. the first line oral treatment has been clomiphene citrate. another anti-estrogen used for ovulation induction is tamoxifen. many unovulatory infertile women are resistance to anti-estrogens and need another treatment. alternative treatments are aromatas inhibitors. objective: this study was designed to compare the effectiveness of...

Objective: To investigate the effect of adding metformin to clomiphene citrate (CC) in polycystic ovarian syndrome (PCOS) patients with acanthosis nigricans (AN) who were previously not responding to CC. Material and Methods: A double blinded randomized controlled trial (NCT02562664) included 66 PCOS women with acanthosis nigricans who were CC resistant (at least 3 months). Day 3 follicle stimu...

Ovulation has been induced by clomiphene citrate and human gonadotropins in infertile women. Clomiphene should be the first choice in anovulatory women with active ovaries as indicated by basic levels of estrogens in blood or urine, in women with post-pill amenorrhea even if their ovaries are quiescent and in women with functional abnormalities of the hypothalamus or pituitary. Human gonadotrop...

PURPOSE To evaluate the pregnancy rate in intrauterine insemination (IUI), and to determine possible prognostic factors of successful pregnancy. METHODS A retrospective study of IUI cycles performed in the Reproductive Medicine Unit of Vila Nova de Gaia Hospital, between January 2007 and July 2010. The IUI cycles were preceded by ovarian stimulation and monitored by vaginal ultrasound. Clinic...