INTRODUCTION AND OBJECTIVE Fistulas represent a significant challenge in the treatment of cleft palate. The best outcome of a palatoplasty is obtained with a competent velopharyngeal sphincter and a palate without fistulas. The recurrence of primary cleft palate fistula is reported as high as up to 76%, and to nearly 100% in recurrent fistulas. Plasma rich in growth factors (PRGF) is an autolog...

BACKGROUND There is a lack of high-level evidence on the surgical management of cleft palate. An appreciation of the differences in the complication rates between different surgical techniques and timing of repair is essential in optimizing cleft palate management. METHOD A comprehensive electronic database search will be conducted on the complication rates associated with cleft palate repair...

OBJECTIVES To identify the implications of living with untreated cleft palate and develop an outcome measure which reflects the broad impact of surgery but is sensitive to the physical impact, speech changes, and psychosocial implications of late intervention. Design, Participants, Setting: Focus groups and individual interviews were used to gather information on the implications of living with...

OBJECTIVE. To investigate cleft disordered tissue in children with cleft palate and cleft lip with or without alveolar clefting for detection of local tissue growth factors and growth factor receptors and compare findings. Design. Morphological analysis of human tissue. Patients. Three groups were studied: 14 patients with cleft palate at the age from eight months to 18 years and two months, 12...

Transcriptional cofactors are essential to the regulation of transforming growth factor beta (TGFbeta) superfamily signaling and play critical and widespread roles during embryonic development, including craniofacial development. We describe the cleft secondary palate 1 (csp1) N-ethyl-N-nitrosourea-induced mouse model of non-syndromic cleft palate (NSCP) that is caused by an intronic Prdm16 spl...

OBJECTIVES Children with cleft lip and palate universally present with otitis media with effusion. This prevalence has not been systematically studied. The purpose of the present study was to examine and compare the prevalence of otitis media with effusion, hearing sensitivity, and audiometry method utilised for assessment in children with and without clefts. METHODS Two groups of children (c...

background cleft lip and palate as the most common congenital defect of oral cavity possesses a heavy socioeconomic burden for both the child and parents. nasoalveolar molding (nam) has received more attention to enhance future facial appearance and function during recent decades case presentation a 21-day old female neonate was referred with a bilateral cleft lip and palate. parents complained...

The aim of this study was to assess the prevalence of caries in children with cleft lip and∕or palate aged 6-36 months of life. This study was conducted at the University of São Paulo School of Dentistry, Brazil. A total of 143 children were selected (73 male, 70 female), all of whom had at least two erupted teeth. The children were distributed as follows: 88 had cleft lip and palate, 35 had cl...

BACKGROUND Mutations of the MSX1 gene may contribute to non-syndromic forms of cleft lip and/or cleft palate. AIM To search for mutations of MSX1 coding regions, including one highly conserved non-coding region in the single intron, among Chilean patients with cleft lip/palate. PATIENTS AND METHODS We studied 45 patients with cleft lip/palate and their parents. Oral mucosa samples were obta...

introduction: a cleft lip with or without a cleft palate is one of the major congenital anomalies observed in newborns. this study explored the risk factors for oral clefts in gorgan, northern iran.  materials and methods: this hospital-based case-control study was performed in three hospitals in gorgan, northern iran between april 2006 and december 2009. the case group contained 33 newborns wi...