A novel method of repeated hepatic dearterialization was evaluated in five patients with multiple metastases from gastric cancer in both hepatic lobes. After gastrectomy with extensive lymph node dissection (R2/3), all patients underwent implantation of a vascular occluder around the hepatic artery. Cannulation of the hepatic artery was added for later chemotherapy. The hepatic artery was occlu...

The development of efficient, cell surface targeted retroviral vectors is critical for successful gene therapy as gene delivery to non-target cells may be harmful and would deplete the pool of viral particles. To date, the only surface-targeting strategies that have allowed efficient infection by retroviral vectors in vivo are those that have limited the tropism of amphotropic murine leukaemia ...

Plasma levels of circulating carcinoembryonic antigen (CEA) were measured by zirconyl phosphate gel radioimmunoassay in 112 patients with chronic inflammatory bowel disease. The levels were then related to category, extent, duration, and severity of disease, as well as to the ages and surgical status of the patients. The distribution of CEA levels and their mean values were significantly raised...

Peritoneal dissemination (PD) of cancer is difficult to diagnose. Previous reports have shown that carbohydrate antigen 125 (CA125) is a sensitive marker of PD of gastric cancer. However, CA125 has not been evaluated as a marker of colorectal cancer (CRC), and its accuracy in men is controversial. The aim of this study was to compare the ability of CA125 and carcinoembryonic antigen (CEA) to pr...

Introduction: Studies have shown that an increase in carcinoembryonic antigen (CEA) is associated with the progression of colorectal cancer and is considered a sensitive diagnostic factor for CRC. Moreover, the role of peroxisome proliferators (PPARs) has recently been considered in colorectal cancer. This study aimed to investigate the relationship between the expression level of PPARs and CEA...

Pleural fluid cytology is usually the initial diagnostic tool in pleural fluid analysis. However, the conventional cytological evaluation of pleural effusion in detecting malignancy has a sensitivity wide range – from 22 to 81%. Measurement of carcinoembryogenic antigen (CEA) level in pleural fluid may be valuable in the diagnosis of malignant pleural effusion. The study was performed on 70 dif...

The common baboon (Papio), immunized with carcinoembryonic antigen (CEA), was found to form specificsite antibodies for CEA. The baboon antiserum does not recognize colon carcinoma antigen-Ill, but does demonstrate similar ionic strength effects to those previously described for goat antisera to the CEA-specific site(s). Baboon specific-site antibody for CEA can be used for radioimmunoassay of ...

Objective: To evaluate the clinical significance of serum levels of Tartrate Resistant Acid Phosphatase 5b (TRACP5b), Carcino-Embryonic Antigen (CEA) and CA-153 in predicting the bone metastasis in patients diagnosed with lymph node-negative breast cancer. Methods: Seventy-seven patients pathologically diagnosed with lymph node-negative breast cancer were recruited in the breast cancer group an...

BACKGROUND Sensitive antibody-based tumor targeting has the potential not only to image metastatic and micrometastatic disease, but also to be the basis of targeted therapy. The vast majority of pancreas cancers express carcinoembryonic antigen (CEA). Thus, we sought to evaluate the potential of CEA as a pancreatic cancer target utilizing a rapidly clearing engineered anti-CEA scFv-Fc antibody ...