JONATHAN SWIFT is one of the greatest geniuses of English letters, and one whose stature increases with the years. In the last few years alone a vast amount of critical and biographical literature about him has been published. In spite of this he remains a most enigmatic personality. His public career abounds with contradictions and paradoxes, and his private life, particularly his relationship...

timur began his domination by the help he received from parts of the chaghataid troops. then and concurrent to extending his realm and power, he recruited defeated populations as new part of his army. simultaneously he established household – provincial powers in his occupations which his sons and grandsons ruled over them. this political – administrative tradition was followed by his successor...

although the majority of the scholars of the arabic prosody share the belief that mutadärik meter was devised and added to the khalili's fifteen meters by akhfash owsat, historical and structural investigations show that this meter can not be his innovation. this article also attempts to introduce the real innovator of mutadärik meter, whom the author of this article believes to be ibn h...

Both the amino-terminal and carboxyl-terminal domains of IGF binding protein (IGFBP)-3 are believed to contribute to high-affinity IGF binding. To investigate cooperativity in IGF binding by these domains, we expressed IGFBP-3 fragments 1-88 (NBP-3) and 185-264 (CBP-3) as FLAG and hexahistidine-tagged fusion proteins, respectively. IGF-I and IGF-II bound to NBP-3 poorly and to CBP-3 with modera...

The major light-harvesting chlorophyll a/b-binding protein (Lhcb1,2) of photosystem II is inserted into the thylakoid via the signal recognition particle dependent pathway. However, the mechanism by which the protein enters the membrane is at this time unknown. In order to define some topographical restrictions for this process, we constructed several recombinant derivatives of Lhcb1 carrying h...

Hairy root culture is a potential alternative to conventional mammalian cell culture to produce recombinant proteins due to its ease in protein recovery, low costs and absence of potentially human pathogenic contaminants. The current study focussed to develop a new platform of a hairy root culture system from Nicotiana tabacum for the production of recombinant human EPO (rhEPO), which is regula...

data collected confirmed the RNA-Seq results. ChIP-Seq methods are being optimized to identify the direct targets of OpaR. Select targets were confirmed direct targets via in vitro electrophoretic mobility shift assays (EMSA) with purified hexahistidine tagged OpaR. A previously published position specific weighted matrix (PSWM) will be utilized to assist in identification of possible OpaR bind...

Ischemia and reperfusion of organs is an unavoidable consequence of transplantation. Inflammatory events associated with reperfusion injury are in part attributed to excessive complement activation. Systemic administration of complement inhibitors reduces reperfusion injury but leaves patients vulnerable to infection. Here, we report a novel therapeutic strategy that decorates cells with an ant...

We had earlier identified the pcnB locus as the gene for the major Escherichia coli poly(A) polymerase (PAP I). In this report, we describe the disruption and identification of a candidate gene for a second poly(A) polymerase (PAP II) by an experimental strategy which was based on the assumption that the viability of E. coli depends on the presence of either PAP I or PAP II. The coding region t...