In the past several years, the importance of microRNA (miRNA) in cancer cells has been recognized. Proper control of miRNA expression is essential for maintaining a steady state of the cellular machinery. Recently, it was discovered that extracellular miRNAs circulate in the blood of both healthy and diseased patients, although ribonuclease is present in both plasma and serum. Most of the circu...

OBJECTIVES A nested case control study of a longitudinal cohort comparing pregnant women enrolled at 10 to 13 gestational weeks was carried out to evaluate risk assessment for preeclampsia and IUGR based on circulating placental specific C19MC microRNAs in early pregnancy. METHODS The expression of placental specific C19MC microRNAs (miR-516b-5p, miR-517-5p, miR-518b, miR-520a-5p, miR-520h, a...

Abstract Background Age-related sarcopenia meaningfully increases the risks of functional limitations and mortality in older adults. Although circulating microRNAs (c-miRNAs) are associated with aging-related cellular senescence inflammation, relationships between c-miRNAs adults remain unclear. This study investigates whether myo-miRNAs inflammation-related miRNAs Methods investigation recruit...

Background After myocardial infarction (MI) complicated by heart failure (HF), eplerenone reduced serum concentrations of amino-terminal propeptide type III collagen (PIIINP) and carboxy-terminal I (PICP). Determining a subgroup who are more prone to decrease their content respond better the antifibrotic effects mineralocorticoid receptor antagonists (MRA) may be relevant for personalized treat...