نتایج جستجو برای: ciliary neurotrophic factor cntfr

تعداد نتایج: 853570  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
N G Forger M L Howell L Bengston L MacKenzie T M DeChiara G D Yancopoulos

Ciliary neurotrophic factor (CNTF) has potent survival-promoting effects on motoneurons in vitro and in vivo. We examined knockout mice with null mutations of the gene for either CNTF itself or the alpha-subunit of the CNTF receptor (CNTFRalpha) to assess whether CNTF and/or its receptors are involved in the development of a sexually dimorphic neuromuscular system. Male rodents have many more m...

Journal: :Oman medical journal 2014
Rashid Al Abri Arif Ali Kolethekkat Michael O Kelleher Lynn M Myles Michael A Glasby

OBJECTIVE to determine whether the administration of Ciliary Neurotrophic Factor (CNTF) at the site of repaired facial nerve enhances regeneration in the adult sheep model. METHODS Ten adult sheep were divided into 2 groups: control and study group (CNTF group). In the CNTF group, the buccal branch of the facial nerve was transected and then repaired by epineural sutures. CNTF was injected ov...

Journal: :bulletin of emergency and trauma 0
ali mehrshad department of clinical sciences, faculty of veterinary medicine, urmia branch, islamic azad university, urmia, iran ashkan seddighnia department of basic sciences, faculty of veterinary medicine, urmia branch, islamic azad university, urmia, iran mohammadreza shadabi department of basic sciences, faculty of veterinary medicine, urmia branch, islamic azad university, urmia, iran alireza najafpour department of basic sciences, faculty of veterinary medicine, urmia branch, islamic azad university, urmia, iran rahim mohammadi department of internal medicine and clinical pathology, faculty of veterinary medicine, urmia university, urmia, iran.

objective: to assess the effect of heparin binding neurotrophic factor (hbnf) on sciatic nerve regeneration in animal model of rat. methods: seventy-five male wistar rats were divided into five experimental groups randomly (each group containing 15 animals): sham operation group (sham), autograft group (auto), transected control (tc), chitosan conduit (chit) and heparin binding neurotrophic fac...

2013
Jason Arsenault Enrico Ferrari Dhevahi Niranjan Sabine A G Cuijpers Chunjing Gu Yvonne Vallis John O'Brien Bazbek Davletov

Precise cellular targeting of macromolecular cargos has important biotechnological and medical implications. Using a recently established 'protein stapling' method, we linked the proteolytic domain of botulinum neurotoxin type A (BoNT/A) to a selection of ligands to target neuroendocrine tumor cells. The botulinum proteolytic domain was chosen because of its well-known potency to block the rele...

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