opsy was also performed in the left inferior conjunctival fornix of the mother’s eye to exclude ocular cicatricial pemphigoid. The biopsy specimen showed a nonspecific monocytic infiltration and epithelial squamous metaplasia. Direct immunofluorescence results were negative for IgG, IgM, IgA, and complement factors (C3 and C4). As expected, magnetic resonance imaging showed marked hypoplasia or...

BACKGROUND A growing body of evidence suggests the involvement of naturally occurring CD4+ CD25+ regulatory (nTreg) T cells in autoimmune diseases. OBJECTIVE To evaluate the expression of some nTreg markers in mucous membrane pemphigoid (MMP) lesions. METHODS Lesional biopsies from six patients with untreated MMP were stained immunohistochemically with anti-CD25, -FoxP3, -CD103, and -CCR5. ...

Eleven patients with cutaneous anthrax of the eyelids are presented. The complications were cicatricial ectropion (eight patients), resulting in corneal scarring (three patients). The ectropion was corrected by full thickness postauricular skin grafts, with good results. The predilection of this infection for the eyelids of young children and a seasonal variation suggest that a vector may be in...

Background. This in vitro study compared the effects of mineral trioxide aggregate (MTA), calcium enriched mixture(CEM) cement, Biodentine (BD) and octacalcium phosphate (OCP) on the viability of human gingival fibroblasts (HGFs). Methods. After completion of the setting time of the materials under study, fibroblasts were placed in 24-well insert platesand 1 mg of each material was added to the...

Trichoscopy is a noninvasive visualization tool used to more accurately diagnose hair and scalp disorders. Alopecia areata (AA) in the patient of African descent can mimic the early signs of central centrifugal cicatricial alopecia (CCCA), especially if the initial presentation of hair loss occurs on the central scalp. Two African-American women presented with singular round-ovoid patches of de...

Purpose To describe a case of bilateral conjunctivitis and cicatricial ectropion associated with dupilumab therapy for atopic dermatitis. Observations Severe hyperemia of the conjunctiva and eyelid margins, as well as cicatricial ectropion, began two months after starting weekly dupilumab injections for atopic dermatitis. The findings worsened over the next several months and improved after d...

BACKGROUND The oral contraceptive pill (OCP) remains the most popular form of prescription contraception in many countries, despite adherence difficulties for many. Uptake of long acting reversible contraceptives (LARCs), which are less reliant on user adherence, remains low. The aim of this study was to explore the experiences of, and attitudes towards, prescription contraception amongst sampl...

OBJECTIVE Sub-epidermal bullous disorders belong to immunobullous diseases which develop as a result of autoantibody action against epidermal basement membrane proteins. Clinically, they are tense bullae and do not rupture easily. They are classified into various forms based on histopathology and direct immunofluorescence patterns. This study was undertaken to assess the incidence of various su...

OBJECTIVE To assess the usefulness of enzyme-linked immunosorbent assay (ELISA) assessment of the combination of bullous pemphigoid antigen 1 (BPAG1) and BPAG2 in the diagnosis of bullous pemphigoid (BP). DESIGN Retrospective study of serum samples from patients with BP. SETTING Tertiary care center. PATIENTS A total of 190 patients with newly diagnosed BP and 78 controls with other autoi...