Background: Chronic wounds are a serious problem for the patient and can increase the socioeconomic burden on the healthcare system and community. This study aimed at investigating the effect of angioplasty on chronic ischemic wound healing. Methods: This study was conducted in Sina Hospital, affiliated to Tehran University of Medical Sciences. Thirty-eight patients with chronic ischemic wounds...

Chronic wounds are that fail to progress through the normal stages of healing and remain open for an extended period time. These often require specialized treatment approaches. While genes involved in wound play important roles chronic as well, specific genetic factors contributing still being studied. Some have been implicated their potential include Transforming Growth Factor-Beta (TGF-β) Fam...

OBJECTIVE Autologous platelet rich plasma is an advanced wound therapy used in hard-to-heal acute and chronic wounds. To better understand the use and clinical outcomes of the therapy, a systematic review of the published literature in cutaneous wounds was performed. METHODS Electronic and hand searches for randomized controlled trials and comparative group studies using platelet rich plasma ...

BACKGROUND Regardless of numerous advances in surgical techniques, selection of the best technique to sew up wounds and the best suture material are still controversial. Several postoperative complications, including wound infection, stitched wound, chronic incision pain, wound dehiscence and hernia stitches result from many factors such as used suture material. OBJECTIVES The aim of the pres...

A wound is any injury that disrupts the structure of healthy skin tissue caused by chemical, mechanical, biological or thermal trauma. Wounds can be classified as acute chronic, depending on their period healing​[1]​. Acute wounds usually heal without complication within ten days; however, chronic do not undergo normal healing processes, commonly have […]

The synthesis and deposition of extracellular matrix (ECM) plays an important role in the healing of acute and chronic wounds. Consequently, the use of ECM as treatment for chronic wounds has been of special interest-both in terms of inducing ECM production by resident cells and applying ex vivo produced ECM. For these purposes, using adipose tissue-derived stem cells (ASCs) could be of use. AS...

Current understanding of the complex process of wound repair is based on decades of study. Integral to this understanding has been the use of in vitro and in vivo models to uncover the key molecular players. Now that major wound processes are more fully understood, therapeutic strategies can be developed to manipulate wound repair. Particularly important areas for future research include develo...

The prevalence of antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus is rapidly increasing in healthcare facilities and spreading to the community. Methicillin-resistant S. aureus colonize the skin and open wounds and can interfere with wound healing. Recent studies have shown that ultraviolet light C can kill antibiotic-resistant strains of bacteria such as methi...

Wound bed preparation is a new approach that integrates proven concepts to build a platform for the treatment of chronic wounds. It organizes currently approved medical procedures and products into a holistic approach that can be used to evaluate and remove barriers to the wound-healing process. Removal of such barriers allows for optimal wound repair and healing. To address these barriers, a s...