نتایج جستجو برای: chronic schizophrenia
تعداد نتایج: 544313 فیلتر نتایج به سال:
Many studies show that oxidative stress is a pathophysiological mechanism of schizophrenia. Elevated oxidative stress levels and the damage to the antioxidant defense system can observed in early schizophrenia. High oxidation levels damage lipids, proteins, nucleic acids and other tissues. Antioxidant defense system imbalance has been observed in both neuroleptic-naïve first-episode schizophren...
The value of maintenance neuroleptic therapy for patients with schizophrenia has been well documented (Kane, 1987; Soni et al 1992). There has been, however, a trend in recent years of prescribing higher than recommended doses of neuroleptics in the treatment of schizophrenia (Reardon et al, 1970). This is in agreement with the unconvincing evidence that higher doses of medication present addit...
Introduction: Schizophrenia is a chronic heterogenic neurodevelopment disorder. Many genes interfere in the development of SCZ. All four genes, NrCAM, PRODH, ANK3, and ANKK1, which were evaluated in this study, were previously reported to be associated with Schizophrenia. The NrCAM contributes to creating cognitive deficiencies through the CAM’s signaling pathway. PRODH plays a vital role in cr...
BACKGROUND The goal of the study was to examine mismatch negativity (MMN) in schizotypal personality disorder (SPD) individuals. Abnormal MMN has been a consistent finding in chronic schizophrenia and there also have been reports of reduced duration MMN in first episode schizophrenia patients [Umbricht, D., Krljes, S., Mismatch negativity in schizophrenia: a meta-analysis. Schizophrenia Researc...
BACKGROUND A shorter duration of untreated psychosis has been associated with better prognosis in schizophrenia. In this study, we measured the duration mismatch negativity (dMMN), an event-related potential, and cognitive performance in subjects with at-risk mental state (ARMS), patients with first-episode or chronic schizophrenia, and healthy volunteers. The main interest was to determine if ...
objectives: saffron is the stigma of crocus sativus l., which has the potentials to play a role in the treatment of many diseases. although many researches are now going on this precious spice, there are few data on saffron safety in human, especially in patients with chronic mental illnesses. this study aimed to evaluate the short-term safety and tolerability of both saffron and crocin (its ma...
Chronic schizophrenics as a group were inferior to controls on tests of neuropsychological function. When divided into groups according to length of illness they differed from each other primarily in tests of language. No other deficits in cognitive function progressed; the performance of the patients on memory, visuo-spatial tasks, rate of information processing and abstract thinking did not d...
Title Brain-wide analysis of functional connectivity in first-episode and chronic stages of schizophrenia Running title: Functional connectivity changes in schizophrenia Word Count: Abstract: 250; MS: 3823 3 figures, 2 tables and a supplement document involving 1 figure and 8 tables. Abstract Published reports of functional abnormalities in schizophrenia remain divergent due to lack of staging ...
Introduction : clozapine is the first effective antipsychotic drug with the least extra pyramidal side effects and more agranulocytosis than other standard neuroleptics. Granolocytopenia or agranulocytosis occurs in 1 to 2 percent of all patients treated with clozapine. agranulocytosis due to clozapine is a fatal disorder that requires immediate clinical intervention. Method : this paper re...
Involvement of the prefrontal cortex in schizophrenia has been implicated by neuropsychological, as well as neuropathological and imaging studies. Reductions of N-acetylaspartate (NAA), an in vivo marker of neuronal integrity, have repeatedly been detected in the frontal lobes of patients with schizophrenia by proton magnetic resonance spectroscopy (1H-MRS). In chronic medicated patients, a pos...
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