نتایج جستجو برای: chronic myeloproliferative disorder
تعداد نتایج: 1043759 فیلتر نتایج به سال:
Activating JAK2 V617F mutation is present in many patients with chronic myeloproliferative neoplasms. We evaluated, retrospectively, clinical and laboratory data from 70 patients with BCR-ABL1 negative, JAK2 positive, chronic myeloproliferative disease. Quantity of the JAK2 mutant allele was tested for correlation with the clinical presentation, type of chronic myeloproliferative disease, hemog...
Introduction Abnormal fibrogenesis is a process which in practically every organ of our body can contribute to disease. In contrast to its paramount importance, too little is known about the pathophysiology of this process and therapeutical ways to interfere with this process. In order to spark progress in the field our idea was to bring together a small group of leading experts of tissue fibro...
The optimal management of patients with polycythemia vera (PV) and essential thrombocythemia (ET) continues to be controversial. Both diseases present diagnostic challenges and there is a paucity of data from randomized clinical trials to guide therapeutic decisions. However, the past two years have seen major advances in our understanding of these myeloproliferative disorders (MPD). First, the...
High concentrations of circulating immune complexes were detected by polyethylene glycol precipitation in 11 of 20 patients with myelofibrosis secondary to chronic myeloproliferative disease. Circulating immune complexes showed a positive correlation with plasma IgG concentrations both in patients and controls. Covariance analysis of the two groups showed significantly increased polyethylene gl...
A recently described atypical myeloproliferative disorder is invariably associated with reciprocal translocations involving 8p11-12. The most common rearrangement is a t(8;13)(p11;q11-12). Here we determine that this translocation results in the fusion of the fibroblast growth factor receptor 1 gene (FGFR1), a member of the receptor tyrosine kinase family at 8p11, to a novel gene at 13q11-12 de...
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with mutation(s) in the JAK2, MPL, or CALR genes. Yet the roles played by these mut...
Myeloproliferative disorders are associated with increased risk of thrombosis and vascular complications. The pathogenesis of these complications is not completely known. Reactive oxygen species produced by the neutrophil NADPH oxidase could have a role in this process. The aim of this study was to evaluate reactive oxygen species production by neutrophils of myeloproliferative disorder patient...
Myelofibrosis (MF) is a rare, chronic myeloproliferative neoplasm. Oncology advanced practitioners (APs), including nurse practitioners, oncology nurses, pharmacists, and physician assistants, who are caring for patients with MF play important roles in patient education and the management of patient expectations. Vigilance in the monitoring of disease progression, treatment response, and advers...
In this issue of Blood, Yan et al and Walz et al exploit mouse genetics to investigate the contribution of signal transducer and activator of transcription 5 (STAT5) to the abnormal in vivo growth of hematopoietic cells expressing JAK2(V617F) or BCR-ABL. Eliminating STAT5 expression had dramatic effects in both contexts, and this new work and other recent studies support the therapeutic potenti...
Michael R. Savona, Luca Malcovati, Rami Komrokji, Ramon V. Tiu, Tariq I. Mughal, Attilio Orazi, Jean-Jacques Kiladjian, Eric Padron, Eric Solary, Raoul Tibes, Raphael Itzykson, Mario Cazzola, Ruben Mesa, Jaroslaw Maciejewski, Pierre Fenaux, Guillermo Garcia-Manero, Aaron Gerds, Guillermo Sanz, Charlotte M. Niemeyer, Francisco Cervantes, Ulrich Germing, Nicholas C. P. Cross, and Alan F. List, on...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید