Cytotoxicity of depleted uranium, as a byproduct of military has been came to spotlight in recent decades. DU is known as a chemical rather than radioactive hazard and efforts to illustrating its mechanism is undergo, but the precise complete molecular mechanisms are still unclear. Recent studies showed that uranium induces biological changes in many different target tissues, such as the kid...

Colliod milium is a degenerative change, which is characterized clinically by development of multiple yellowish, translucent papules and nodules on the light exposed skin and histologically by the presence of colloid in the dermal papillae. This is a rare condition and has some variants. We report a case of colloid millium with nodular and plaque lesions on his ears. Our patient was a far...

Tests for acute oral toxicity, eye irritation, corrosion and dermal toxicity of colloidal silver nanoparticles (AgNPs) were conducted in laboratory animals following OECD guidelines. Oral administration of AgNPs at a limited dose of 5,000 mg/kg produced neither mortality nor acute toxic signs throughout the observation period. Percentage of body weight gain of the mice showed no significant dif...

Antibiotic resistance to microorganisms is one of the major problems faced in the field of wound care in burns patients. Silver nanoparticles have come up as potent antimicrobial agent and are being evaluated in diverse medical applications ranging from silver based dressings to silver coated medical devices. We aimed in present study to test the release of nanosilver from nanosilver wound dres...

Conning, D. M., and Hayes, M. J. (1970). Brit.J.industr.Med.,27, 155-159. The dermal toxicity of phenol: an investigation of the most effective first-aid measures. The percutaneous toxicity of phenol in the Alderley Park (Wistar derived specific pathogen free) rat was determined and was shown to be increased by the diluents water, methylated spirit or olive oil. The toxicity was related to the ...

Pentasodium Pentetate and Pentetic Acid function as chelating agents in cosmetics. Pentasodium Pentetate is readily soluble in water, but the corresponding free acid is not. Pentasodium Pentetate is used in almost 400 cosmetic products over a wide range of product categories, although it is mostly used in hair dyes and colors at use concentrations of 0.1% to 1.0%. Pentetic Acid is used in 150 c...

BACKGROUND Transforming growth factor-beta (TGF-beta) has been identified as an important component of wound healing. Recent developments in molecular therapy offer exciting prospects for the modulation of wound healing, specifically those targeting TGF-beta. The purpose of this study was to analyze the effect of TGF-beta targeting on the expression of matrix metalloproteinases (MMPs) in fibrob...

Background and objectives: Solanum trilobatum plant parts such as berries and flowers are normally used for the treatment of respiratory illnesses. The toxicity profile of the plant and its parts are not clear. Hence, the present study was planned to investigate the toxicological effects of ethanol extract of leaves of S. trilobatum (EEST) using acute and sub-...

This study evaluated local and systemic reactions after an intravascular injection of polymethylmethacrylate (PMMA) at two concentrations in a murine model. Thirty rats were divided equally into three groups: 2% PMMA, 30% PMMA, and a control group (normal saline only injection). The filler was injected into the ranine vein. The rats were sedated at 7 and 90 days and a clinical evaluation perfor...

Rachel L. Chin, MD*, Kent R. Olson, MD**, Delia Dempsey, MS, MD*** *Professor of Clinical Medicine, University of California, San Francisco School of Medicine. San Francisco General Hospital, SF, CA **Medical Director, San Francisco Bay Area Regional Poison Control Center, Associate Clinical Professor of Medicine, University of California, San Francisco, SF, CA ***Assistant Adjunct Professor of...