Abstract Background Chronic neuropathic pain syndrome is associated with impaired quality of life and poorly manageable. Alpha lipoic acid (ALA) a powerful antioxidant showed its effectiveness on diabetic neuropathy other acute peripheral nerve injuries but it was not evaluated in the chronic pain, constriction injury (CCI) rat model by using duloxetine (DLX) as standard. Methodology The main o...


 Purpose: To investigate the effect of miR-339 on neuropathic pain.
 Methods: A rat pain model was established through chronic constriction injury (CCI). Expression in spinal cord determined 14 days later. Microglial inflammatory response evaluated using immunofluorescence analysis ionized calcium binding adaptor molecule 1 (Iba1), while IL-6 and TNF-α were assessed by enzyme-linked ...